Nitrosyl Switch in STING Fuels Alzheimer’s Brain Inflammation

Researchers identify S-nitrosylation of the immune protein STING at cysteine 148 as a driver of brain inflammation in Alzheimer's; blocking this switch in mice reduced inflammation and protected synapses, with the same pathway active in human Alzheimer’s samples and stem-cell models, suggesting a new therapeutic target that dampens harmful inflammation without shutting down normal immunity.