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Nitrosylation Switch in STING Drives Alzheimer’s Brain Inflammation, Study Finds
health-and-medicine1 month ago

Nitrosylation Switch in STING Drives Alzheimer’s Brain Inflammation, Study Finds

Researchers at Scripps Research identified a chemical change known as S-nitrosylation of the STING protein at cysteine 148 that pushes brain immune cells into chronic inflammation in Alzheimer’s disease. Blocking this modification in a mouse model reduced neuroinflammation and protected synapses, and the same pathway was observed in human Alzheimer’s brain tissue and stem-cell models, suggesting a targeted therapy that quiets harmful inflammation without suppressing normal immunity. The team plans preclinical testing of small molecules to block cysteine 148.

via ScienceDaily|
#alzheimers-disease#cysteine-148#health-and-medicine
Sting Turns Homegrown Tale Into a Global Stage with The Last Ship
entertainment2 months ago

Sting Turns Homegrown Tale Into a Global Stage with The Last Ship

Sting’s decade-in-the-making musical The Last Ship, about Newcastle’s shipyards, tours Europe and Australia with Shaggy and is headed to New York’s Metropolitan Opera; the project blends Sting’s personal history with themes of work and identity, underscoring his ongoing commitment to both music and theatre at age 74 while addressing contemporary concerns like AI.

via CBS News|
#entertainment#newcastle#shaggy
Nitrosyl Switch in STING Fuels Alzheimer’s Brain Inflammation
science2 months ago

Nitrosyl Switch in STING Fuels Alzheimer’s Brain Inflammation

Researchers identify S-nitrosylation of the immune protein STING at cysteine 148 as a driver of brain inflammation in Alzheimer's; blocking this switch in mice reduced inflammation and protected synapses, with the same pathway active in human Alzheimer’s samples and stem-cell models, suggesting a new therapeutic target that dampens harmful inflammation without shutting down normal immunity.

via SciTechDaily|
#alzheimers-disease#neuroinflammation#s-nitrosylation
Blocking a STING Switch Could Slow Alzheimer’s Brain Inflammation
science2 months ago

Blocking a STING Switch Could Slow Alzheimer’s Brain Inflammation

Researchers pinpoint S-nitrosylation of the STING protein at cysteine 148 as a driver of chronic brain inflammation and synapse loss in Alzheimer’s. In mouse models, preventing this modification reduced inflammation and protected synapses, a result mirrored in human Alzheimer’s tissue and stem-cell models. The findings suggest a targeted therapy that dampens harmful inflammation without suppressing overall immunity, with small molecules designed to block the cysteine-148 site in development.

via Neuroscience News|
#alzheimers-disease#cysteine-148#neuroinflammation
Darby Allin dethrones MJF for AEW World Title with Sting by his side
aew2 months ago

Darby Allin dethrones MJF for AEW World Title with Sting by his side

Darby Allin defeated Maxwell Jacob Friedman to win the AEW World Championship on Dynamite SpringThru, with Sting making a rare appearance that amplified the moment. Though the setup was telegraphed, the title change still surprised many and sparks discussion about MJF’s reign and future plans, including possible heat toward All In Wembley and potential feuds with Will Ospreay and Kenny Omega.

via Cageside Seats|
#aew#aew-dynamite#darby-allin
Sting Faces London High Court Over Police Royalties Split
business5 months ago

Sting Faces London High Court Over Police Royalties Split

The Police royalties case has moved to London’s High Court, with Sting admitting he has paid Summers and Copeland about $800,000 (and Summers/Copeland noting a recent $870,000 payment) toward what they say is an underpayment from download and streaming revenue. Summers and Copeland contend there was an oral agreement later formalized to share royalties, and assert they’re owed more than $2 million; Sting’s side argues streaming is a public-performance issue and royalties should be limited to sales of records. The dispute centers on how the band’s late-1990s/2010s contracts should be interpreted in the streaming era. None of the members attended today’s preliminary hearing as the case progresses.

via MusicRadar|
#business#copeland#royalties
Sting shells out over £500k in Police royalties amid streaming dispute
music5 months ago

Sting shells out over £500k in Police royalties amid streaming dispute

Sting has paid his former Police bandmates Andy Summers and Stewart Copeland more than £500,000 in royalties after acknowledging underpayment; court filings reveal a recent payment of about $870,000 while Summers and Copeland claim they are owed more than $2 million in publishing income. They argue an oral agreement from 1977, later formalised, entitled them to a 15% share of income from songs like Roxanne and Every Breath You Take, including streaming revenue, whereas Sting’s side says streaming income isn’t royalty-bearing under their 2016 contract (which covers manufacturing) and that the case should not extend to download/digital royalties. The London High Court is considering whether to allow new arguments to claim streaming and download royalties under older contracts, a dispute rooted in The Police’s 1977–84 era, a 2007 reunion, and Sting’s 2022 sale of his songwriting catalogue to Universal Music Group.

via BBC|
#music#royalties#sting
AEW WrestleDream 2025: Recap, Results, and Streaming Guide
wrestling8 months ago

AEW WrestleDream 2025: Recap, Results, and Streaming Guide

AEW WrestleDream 2025 featured a brutal I Quit match where Jon Moxley quit after a violent contest with Darby Allin, with Sting making a surprise appearance. The event also included title defenses, heel turns, record-breaking wins, and exciting matches across the card, culminating in a mixed reception to the spectacle and ongoing storylines.

via Cageside Seats|
#aew-wrestledream-2025#darby-allin#i-quit-match
Former Police Bandmates Sue Sting Over Unpaid Royalties
entertainment10 months ago

Former Police Bandmates Sue Sting Over Unpaid Royalties

Andy Summers and Stewart Copeland are suing Sting over unpaid royalties for the 1983 hit 'Every Breath You Take,' claiming they were not properly credited as songwriters and have not received their share of the song's substantial earnings. The case, filed in London, highlights ongoing disputes over songwriting credits and royalties for the iconic track.

via Louder|
#entertainment#every-breath-you-take#legal-dispute
Sting Faces Lawsuit from Ex-Police Bandmates Over Royalties
entertainment10 months ago

Sting Faces Lawsuit from Ex-Police Bandmates Over Royalties

Sting is being sued by his former Police bandmates, Andy Summers and Stewart Copeland, over alleged unpaid royalties and lack of songwriting credits for the hit song 'Every Breath You Take,' with the case filed in London high court. The band members claim they have not received compensation or recognition for their contributions, while Sting's spokesperson denied the allegations. The lawsuit highlights ongoing disputes over music rights and royalties among legendary artists.

via The Guardian|
#entertainment#lawsuit#police
UVA Researchers Find Immune System Key to Alzheimer’s Treatment
health1 year ago

UVA Researchers Find Immune System Key to Alzheimer’s Treatment

A study from UVA reveals that the immune molecule STING, which becomes hyperactive with age, contributes to Alzheimer's disease by promoting harmful brain inflammation. Blocking STING in mice prevented plaque buildup, protected neurons, and improved memory, suggesting it as a promising therapeutic target for Alzheimer's and other neurodegenerative diseases.

via Neuroscience News|
#alzheimers#brain-inflammation#health
"Sting's Son Reflects on His Father's Final Match and Legacy in AEW"
sports-entertainment2 years ago

"Sting's Son Reflects on His Father's Final Match and Legacy in AEW"

Sting's sons Garrett and Steve Jr. participated in Sting's last match at AEW Revolution, dressing up as past versions of Sting and hitting The Young Bucks with Stinger splashes. Garrett, who runs a YouTube channel focused on Destiny 2, explained his absence from posting videos, expressing pride in his father's legendary career and the overwhelming support from fans, calling the event "the coolest night" of his life.

via Yahoo Entertainment|
#aew-revolution#garrett#sports-entertainment