Novel DL-1 compound slashes LDL cholesterol without fatty liver

Researchers screened thousands of compounds in lab-grown human liver cells and identified DL-1, a triazine thiol, that lowers apoB and reduces total cholesterol without causing fatty liver; in mice with humanized livers, a soluble DL-27 version lowered cholesterol metrics, suggesting a safer alternative for severe inherited high cholesterol (familial hypercholesterolemia) beyond current statins.