Tag

Cholesterol

All articles tagged with #cholesterol

health4 hours ago•15 min saved

Keto Artery-Health Claim Retracted Amid Data Flaws

A 2025 study published in JACC Advances that claimed ketogenic diets don’t promote arterial plaque buildup has been retracted after concerns about selective reporting, questionable control groups, and data anomalies; critics described the authors as social‑media influencers, and coauthor Nicholas Norwitz says they requested the retraction after a deeper analysis revealed anomalies. Retraction Watch published a detailed postmortem, while the authors have posted a reanalysis and continue keto research.

via Gizmodo|

#cardiology #cholesterol #data-analysis

biotech23 hours ago•2 min saved

Lilly’s one-dose gene editor cuts LDL by 62% in early trial

Eli Lilly’s high-dose, one-time gene-editing therapy VERVE-102 lowered LDL cholesterol by 62% in a Phase 1 trial, with no treatment-related serious adverse events, signaling potential for a single-shot approach to prevent heart disease after Lilly’s $1 billion acquisition of Verve Therapeutics.

via statnews.com|

#biotech #cholesterol #eli-lilly

science9 days ago•36 min saved

Novel DL-1 compound slashes LDL cholesterol without fatty liver

Researchers screened thousands of compounds in lab-grown human liver cells and identified DL-1, a triazine thiol, that lowers apoB and reduces total cholesterol without causing fatty liver; in mice with humanized livers, a soluble DL-27 version lowered cholesterol metrics, suggesting a safer alternative for severe inherited high cholesterol (familial hypercholesterolemia) beyond current statins.

via Earth.com|

#apob #cholesterol #dl-1

health11 days ago•264 min saved

CRP Takes the Lead in Heart-Disease Risk Prediction, Prompts Universal Screening

C-reactive protein (CRP), a marker of inflammation, may predict heart disease risk more accurately than LDL cholesterol, leading to ACC recommendations for universal CRP screening alongside cholesterol tests; however cholesterol remains relevant, and a comprehensive risk assessment also considers apolipoprotein B and lipoprotein(a), with prevention rooted in diet, exercise, sleep, stress management, weight control, and smoking cessation.

via AOL.com|

#apolipoprotein-b #c-reactive-protein #cholesterol

health21 days ago•6 min saved

NIH Trial Analysis Links Lipoprotein(a) to Increased Stroke and Death Risk

A study analyzing stored plasma from 20,070 participants in the ACCORD, PEACE, and SPRINT NIH trials found elevated Lipoprotein(a) levels (>=175 nmol/L) are linked to higher residual cardiovascular risk despite standard therapy: about 31% more major adverse cardiovascular events (MACE), 49% higher cardiovascular death risk, and 64% higher stroke risk, with stronger effects in those with existing heart disease; the level was not linked to a higher risk of heart attack. Testing Lp(a) could guide risk assessment and, as new targeted therapies emerge, drive more aggressive management of cholesterol and other risk factors.

via SciTechDaily|

#cardiovascular-risk #cholesterol #health

health28 days ago•7 min saved

Cholesterol Wins With Cardio and Weights Together

Experts say the best cholesterol improvements come from a blend of aerobic cardio and resistance (weight) training. Cardio lowers LDL, vLDL and triglycerides while raising HDL function; resistance training also raises HDL about as much as cardio and can improve LDL, vLDL and triglycerides with consistent effort. For meaningful change, aim to burn about 1,000–1,200 calories per week (roughly five 50‑minute cardio sessions) and train 2–3 times weekly for resistance. If you stay consistent, you may see lipid improvements in 4–8 weeks; combining exercise with diet changes yields the biggest LDL reductions (20–30%).

via Men's Health|

#cardio #cholesterol #hdl

science29 days ago•7 min saved

Sterol-Pathway Meds in Pregnancy Tied to Higher Autism Risk, Large U.S. Study Finds

A national study of 6.14 million U.S. births links prenatal exposure to sterol biosynthesis‑inhibiting medications (SBIMs)—a class including certain antidepressants, antipsychotics, beta-blockers, and statins—with increased autism risk in children. Any SBIM exposure raised ASD risk about 1.47-fold, increasing to 2.33-fold for four or more SBIMs used concurrently. SBIM exposure grew from 4.6% of pregnancies in 2014 to 16.8% in 2023. The researchers stress cautious prescribing during pregnancy, the need for safer options when possible, and further research into the mechanisms, noting many SBIMs are medically necessary.

via SciTechDaily|

#autism #cholesterol #medications

health29 days ago•17 min saved

Lower LDL targets push earlier, risk-based heart prevention

Doctors lowered the LDL cholesterol targets and tied them to an individual’s overall cardiovascular risk, enabling earlier, risk-driven prevention. The guidance uses the PREVENT calculator to decide when lifestyle changes suffice versus when medications should begin, with statins remaining first-line and quicker escalation to ezetimibe or injections if needed. The update also recommends testing lipoprotein(a) and apolipoprotein B, considers targeted imaging in uncertain cases, and calls for earlier screening (adults at 19; kids around 9–11) to detect inherited hypercholesterolemia and start prevention before emergencies.

via Earth.com|

#cardiovascular-risk #cholesterol #health

health-and-wellness29 days ago•3 min saved

Move to Lower LDL: How Exercise Shapes Your Cholesterol

Regular aerobic exercise, at least 120 minutes per week (about 20 minutes daily), can modestly lower LDL by 3–6 mg/dL and improve triglycerides and HDL; a combination of cardio and strength training yields the strongest cholesterol-related benefits and broader heart-health gains.

via USA Today|

#cholesterol #exercise #hdl

health1 month ago•4 min saved

7 Easy Heart-Healthy Swaps That Taste Great

Cardiologist Dr. Evan Shlofmitz shares seven simple, tasty swaps to boost heart health: swap fried potato chips for plantain chips (more fiber, less processing); flavor coffee with cinnamon to cut added sugar and cream; use seasoned olive oil to reduce saturated fat and sodium; replace high-sodium flavorings with miso paste; opt for all-natural frozen fruit pops instead of ice cream; choose heart-healthy fish like rainbow trout (or other fish) instead of red/processed meats; and prefer 100% whole-grain or sprouted bread for fiber and satiety. Coupled with regular activity and label reading, these choices can improve cholesterol, blood pressure, blood sugar and weight over time.

via New York Post|

#cholesterol #diet #health

health1 month ago•7 min saved

ApoB Blood Test Promises Better Heart-Health Guidance Than LDL

A Northwestern Medicine study in JAMA finds apoB testing may more accurately identify cardiovascular risk than LDL or non-HDL cholesterol, and guiding cholesterol-lowering treatment with apoB could prevent more heart attacks and strokes at a cost-effective rate, based on a large lifetime simulation of 250,000 adults and intensified therapy with statins and ezetimibe.

via SciTechDaily|

#apob #cholesterol #cost-effectiveness

health-and-wellbeing1 month ago•1 min saved

Cholesterol risk isn’t about weight alone—genetics and fat intake matter

High LDL cholesterol raises heart attack and stroke risk, but being lean doesn’t guarantee safety; genetics and saturated-fat intake largely drive LDL levels. Obesity mainly affects other lipids (triglycerides and remnant cholesterol) and is linked to diabetes and high blood pressure, which can make LDL more harmful. Overall cardiovascular risk isn’t determined by LDL alone, so a clinician should assess it—consider NHS checks from age 40 and family history of early heart disease.

via The Guardian|

#cardiovascular-risk #cholesterol #genetics

health1 month ago•4 min saved

Cholesterol Risk: Only a Blood Test Tells If It's Too High

Cardiologists say the only reliable way to know if cholesterol is too high is a blood test. High LDL and low HDL increase heart-disease risk, and new guidelines call for regular lipid screening—from childhood through adulthood (every five years) and measuring lipoprotein(a) at least once. Most people have no early symptoms, so routine testing plus healthy lifestyle choices (diet, exercise, no smoking) are key; signs like chest pain or shortness of breath usually appear only after disease has progressed.

via Prevention|

#cholesterol #health #ldl

health1 month ago•52 min saved

Garlic-based supplements: modest heart benefits, uncertain long-term outcomes

Garlic supplements may modestly lower LDL cholesterol and blood pressure, but no garlic product has proven to reduce heart attacks or strokes; bioavailability varies, supplement quality is inconsistent, and doctors often recommend real garlic over concentrated pills due to limited long-term data and possible GI or bleeding side effects.

via Daily Mail|

#allicin #blood-pressure #cholesterol

health1 month ago•1 min saved

New cholesterol guidelines urge earlier action, starting in your 30s

New guidelines from the American College of Cardiology and other groups push for earlier attention to cholesterol—potentially starting around age 30—with clearer targets and guidance on when medications like statins may help, alongside lifestyle changes; doctors emphasize regular cholesterol screening and personalized risk assessment to reduce heart disease and stroke risk.

via The New York Times|

#cardiovascular-health #cholesterol #cholesterol-guidelines