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Apob

All articles tagged with #apob

health3 days ago•5 min saved

Beyond cholesterol: seven hidden heart-risk factors doctors check

Heart attack risk isn’t determined by cholesterol alone. Doctors emphasize the broader metabolic picture—blood pressure, blood sugar, abdominal obesity, physical activity, sleep, and family history—to assess risk. Some important markers not in routine lipid tests, like lipoprotein(a) and ApoB, can provide a clearer view of atherogenic risk, and coronary artery calcium scoring via CT can reveal existing plaque in selected individuals. Even with normal cholesterol, symptoms such as chest discomfort or breathlessness should be evaluated. The goal is to identify the right risk factors for each person and intervene early, recognizing that heart health is a mix of factors rather than a single number.

via The Times of India|

#apob #cac-scoring #cardiovascular-risk

health1 month ago•11 min saved

ApoB testing could redefine cholesterol screening, surpassing LDL in predicting heart risk

A new JAMA study finds measuring apolipoprotein B (apoB) in cholesterol screening may more accurately identify who needs treatment to prevent heart attacks and strokes than LDL or non-HDL cholesterol. The findings align with updated guidelines that emphasize additional tests, like Lp(a), for assessing risk, and suggest apoB can reveal cardiovascular risk even when LDL appears normal.

via USA Today|

#apob #health #heart-disease

health1 month ago•14 min saved

ApoB Test Could Refine Heart-Risk Assessment Beyond LDL

A recent JAMA study suggests that the apolipoprotein B (apoB) test, which counts harmful cholesterol particles, may identify people at risk for heart attack or stroke more accurately than standard LDL measurements; using apoB to guide when to intensify statin therapy could prevent more cardiovascular events, but it should be used as an additive tool alongside the regular lipid panel, especially for those with diabetes, obesity, metabolic syndrome, or high triglycerides.

via NDTV|

#apob #cardiovascular-risk #cholesterol-testing

health1 month ago•6 min saved

ApoB Testing Could Sharpen Cholesterol Therapy Decisions

A Northwestern Medicine study in JAMA finds that apoB testing, which counts harmful cholesterol particles, better guides the decision to intensify cholesterol-lowering therapy than LDL or non-HDL testing, potentially preventing more heart attacks and strokes while remaining cost-effective for U.S. healthcare, based on a computer model comparing three strategies in 250,000 adults.

via ScienceDaily|

#apob #cardiovascular-disease #cost-effectiveness

health1 month ago•8 min saved

New ACC/AHA cholesterol guidelines push early prevention and broader testing

The ACC/AHA's updated cholesterol guidelines urge starting prevention early, expand testing beyond traditional cholesterol (including Lp(a) and ApoB) and use risk tools like CAC scanning to tailor treatment. They emphasize lifestyle first—plant-based, whole foods, limited ultra-processed foods, regular exercise, stress management, and adequate sleep—with routine cholesterol checks for adults 19+ and childhood screening for those with family history. While lifestyle changes are central, medications such as statins may be necessary for some, and supplements are not a reliable shortcut. Prevention is a lifelong commitment.

via The Times of India|

#apob #cholesterol #guidelines

health1 month ago•7 min saved

Five Under-the-Radar Lab Tests Women 40+ Should Request

Dr. Jennifer Roelands argues that standard wellness panels miss key midlife risks for women and recommends five essential tests: ApoB and Lp(a) for cardiovascular risk; fasting insulin for metabolic health; vitamin D and ferritin for nutrient status; a full thyroid panel (TSH, free T3/T4, antibodies); and free/total testosterone with SHBG to inform treatment decisions. These tests are not usually part of routine panels but enable proactive, precision care during perimenopause; bring this list to your next appointment or order the tests yourself if necessary.

via MindBodyGreen|

#apob #fasting-insulin #ferritin

health2 months ago•5 min saved

Four overlooked markers that reveal heart and stroke risk years before symptoms

LDL alone doesn’t tell the full story. Beyond cholesterol, ApoB particle count, hs-CRP (inflammation), insulin resistance, and abdominal obesity can together provide a clearer, earlier warning of heart attack or stroke risk, helping guide preventive care.

via The Times of India|

#abdominal-obesity #apob #cardiovascular-risk

science3 months ago•36 min saved

Novel DL-1 compound slashes LDL cholesterol without fatty liver

Researchers screened thousands of compounds in lab-grown human liver cells and identified DL-1, a triazine thiol, that lowers apoB and reduces total cholesterol without causing fatty liver; in mice with humanized livers, a soluble DL-27 version lowered cholesterol metrics, suggesting a safer alternative for severe inherited high cholesterol (familial hypercholesterolemia) beyond current statins.

via Earth.com|

#apob #cholesterol #dl-1

health4 months ago•33 min saved

High LDL on keto isn’t risk-free: experts reaffirm LDL-apoB causality

A skeptical review of the lean mass hyper-responder (LMHR) hypothesis argues that very high LDL-C on a ketogenic diet does not erase the proven link between apoB-containing particles and atherosclerosis. It critiques two LMHR studies for short duration, lack of proper controls, and confounding factors, and questions the lipid-energy model’s validity. Across decades of evidence, LDL-C/apoB remains causally related to ASCVD, so reducing apoB—through diet, statins, or other therapies—remains the prudent course, even for metabolically healthy individuals. Longer-term, well-controlled data would be required to overturn this consensus.

via peterattiamd.com|

#apob #atherosclerosis #health

health4 months ago•7 min saved

ApoB Blood Test Promises Better Heart-Health Guidance Than LDL

A Northwestern Medicine study in JAMA finds apoB testing may more accurately identify cardiovascular risk than LDL or non-HDL cholesterol, and guiding cholesterol-lowering treatment with apoB could prevent more heart attacks and strokes at a cost-effective rate, based on a large lifetime simulation of 250,000 adults and intensified therapy with statins and ezetimibe.

via SciTechDaily|

#apob #cholesterol #cost-effectiveness

health4 months ago•7 min saved

ApoB testing could steer cholesterol care toward fewer heart attacks and strokes

A Northwestern-led simulation study finds using apoB levels to guide cholesterol-lowering therapy may prevent more heart attacks and strokes over a lifetime and be cost-effective compared with LDL- or non-HDL-guided strategies, though apoB testing isn’t yet routine due to extra testing, cost, and current guideline adoption.

via Medical News Today|

#apob #cardiovascular-risk #cholesterol-testing

science4 months ago•9 min saved

Scientific Breakthrough Aims to Cut LDL Particles by Blocking ApoB Production

Researchers at the Medical University of South Carolina are pursuing a treatment for familial hypercholesterolemia by reducing apoB, the backbone of LDL particles, using human iPSC-derived liver cells to screen about 130,000 compounds. A lead class lowered apoB release and cellular lipid levels in human cells and in humanized mice, bypassing the LDL receptor and potentially helping patients with defective receptors. Further work will clarify the mechanism, safety, and how such drugs could complement existing therapies like statins.

via SciTechDaily|

#apob #drug-discovery #familial-hypercholesterolemia

health6 months ago•47 min saved

Soap Star Melissa Claire Egan Speaks Out on Coronary Heart Disease Diagnosis

Melissa Claire Egan, known for The Young and the Restless, revealed she was diagnosed with coronary heart disease in late January after a heart calcium scan found mild plaque in her LAD artery; she emphasizes early detection and urges other women to get evaluated, including Lipoprotein(a) and ApoB testing, and to seek heart-health screening alongside awareness efforts with the American Heart Association.

via Soap Opera Digest|

#apob #coronary-heart-disease #health

health8 months ago•2 min saved

Top Indicators and Lifestyle Tips to Prevent Heart Attacks in Young Adults

Neurologist Dr. Priyanka Sehrawat emphasizes that normal cholesterol levels do not necessarily indicate low heart attack risk, highlighting two key markers—ApoB and Lipoprotein(a)—as stronger predictors of cardiovascular events, especially in individuals with a family history or metabolic dysfunction.

via Hindustan Times|

#apob #cholesterol #health

health9 months ago•85 min saved

Urgent Warning: Prevent Heart Disease

The article discusses skepticism around current heart disease prevention practices, highlighting issues with reliance on proxy indicators like LDL-C instead of direct measures like ApoB, questioning the effectiveness and motivations behind widespread statin use, and emphasizing the importance of lifestyle changes and better diagnostic tools for truly assessing and reducing cardiovascular risk.

via Hacker News|

#apob #cholesterol #health