One psilocybin dose may reshape brain networks and boost well-being for weeks

A study of 28 healthy adults found that a single 25 mg dose of psilocybin increased brain entropy within an hour and, one month later, showed denser neural connections on diffusion tensor imaging. Participants who experienced greater insight after dosing reported improved well-being a month later, suggesting the psychedelic experience may help rewire entrenched thought patterns and inform future mental-health therapies.