RNA-Driven Chromatin Shredding Targets Cancer Mutations
TL;DR
Researchers engineered an RNA-guided CRISPR-Cas12a2 nuclease to recognize cancer-specific transcripts and trigger transcript-activated chromatin shredding, leading to DNA damage responses and selective death of cancer cells in experimental systems, offering a potential precision approach to targeting undruggable mutations such as p53.
- Targeting Cancer-Specific Mutations with RNA-Triggered Chromatin Shredding Nature
- Could cave bacteria help cure cancer? A USU discovery suggests they might Utah Public Radio
- CRISPR Shreds Undruggable Cancer Cells with Precision Genetic Engineering and Biotechnology News
- RNA-Triggered Chromatin Shredding Targets Cancer Mutations Bioengineer.org
- Breakthroughs in CRISPR technology on Access Utah Utah Public Radio
Want the full story? Read the original reporting
Read on Nature