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Crispr

All articles tagged with #crispr

Colossal’s de-extinction bid stirs science and ethics debate
science24 days ago

Colossal’s de-extinction bid stirs science and ethics debate

Dallas-based Colossal Biosciences is pursuing revival of extinct species—including dire wolves and the dodo—using ancient DNA and CRISPR. The effort has drawn praise for pushing conservation tech and public engagement, but also sharp criticism from scientists who question feasibility and ecological risks, warn against conflating revived animals with extinct ones, and worry about undermining habitat protection; supporters see potential conservation benefits and genetic diversity applications, while critics urge caution and rigorous science.

via The Guardian|
#colossal-biosciences#conservation#crispr
Miracle CRISPR treatment cures stage 4 colon cancer in a 12-patient trial
health26 days ago

Miracle CRISPR treatment cures stage 4 colon cancer in a 12-patient trial

Emma Weston-Dimery, diagnosed with stage 4 colon cancer at 23, was one of 12 patients in a Phase 1 trial of CRISPR-Cas9 gene-edited immune cells. After cells were edited to better attack the cancer and reinfused in early 2023, two nodules disappeared within a month and the remaining cancer vanished by month two. She is now cancer-free, the only patient in the trial to achieve complete remission. The study showed mixed results for others, with some stabilization and several deaths due to the disease. A Phase 2 trial and a pill-form version of the therapy are planned, and Weston-Dimery is now an advocate for clinical trials and patient awareness.

via Daily Mail|
#cancer-survivor#cancer-trial#colon-cancer
Gene-edited fungus could turbocharge meat substitutes and slash environmental footprint
technology1 month ago

Gene-edited fungus could turbocharge meat substitutes and slash environmental footprint

A gene-edited fungus used to make mycoprotein grows protein nearly twice as fast with far less sugar after deleting two genes with CRISPR to thin its cell wall; lifecycle analyses across six countries show substantial reductions in climate emissions, land use, and freshwater pollution, plus improved essential amino-acid quality. Regulators and large-scale production hurdles remain before it reaches diners.

via Earth.com|
#crispr#fungus#gene-editing
Brain’s DeltaFosB as Switch Behind Cocaine Relapse, Study Finds
science1 month ago

Brain’s DeltaFosB as Switch Behind Cocaine Relapse, Study Finds

Chronic cocaine use rewires the brain by accumulating DeltaFosB in the ventral hippocampus–nucleus accumbens reward-memory circuit, altering gene expression and driving compulsive drug-seeking. CRISPR experiments show DeltaFosB is necessary for these changes, and calreticulin helps rev the brain’s engine toward cocaine seeking. With no FDA-approved meds for cocaine addiction, researchers are pursuing DeltaFosB-targeting compounds as a potential future treatment to reset brain circuits and reduce relapse.

via Neuroscience News|
#calreticulin#cocaine-addiction#crispr
Brain Cells with a Built-In Defense Against Dementia Found
science1 month ago

Brain Cells with a Built-In Defense Against Dementia Found

A CRISPR-based screen in human neurons with disease-causing tau mutations identified the CRL5SOCS4 protein complex as a key driver of tau protein degradation, helping some brain cells resist toxic tau clumps and dementia. Findings align with brain atlas data showing higher CRL5SOCS4 expression correlates with cell survival, and researchers note mitochondrial dysfunction can increase pathogenic tau fragments. Potential therapies include boosting CRL5SOCS4 activity or protecting proteasomes to enhance tau clearance.

via ScienceAlert|
#alzheimers-disease#crispr#mitochondria
Coffee-Triggered CRISPR: A Reversible Jab at Precision Gene Therapy
science2 months ago

Coffee-Triggered CRISPR: A Reversible Jab at Precision Gene Therapy

Texas A&M researchers report a chemogenetic system that links CRISPR activity to caffeine, enabling controllable, reversible gene editing and T‑cell activation via a “caffebody,” with safety shutoffs using rapamycin. This approach aims for more precise cancer therapies and other long‑term treatments, pending further preclinical studies.

via SciTechDaily|
#caffeine#cancer-therapy#chemogenetics
First-Ever Personalized CRISPR Therapy Helps Infant With CPS1 Deficiency Thrive
science2 months ago

First-Ever Personalized CRISPR Therapy Helps Infant With CPS1 Deficiency Thrive

Researchers at Children’s Hospital of Philadelphia and the University of Pennsylvania developed a bespoke base-editing CRISPR therapy delivered to the liver to fix a CPS1 gene variant in a newborn with a rare metabolic disorder. After a first infusion in early 2025 and subsequent doses, the child has tolerated treatment with no adverse effects, has been able to halt medications and gradually reintroduce protein, and is thriving per a New England Journal of Medicine report; the approach is experimental and not FDA-approved, but signals a path toward patient-specific gene therapies that could be scalable to individual needs.

via Good News Network|
#cps1-deficiency#crispr#gene-therapy
Diverse autism mutations converge on a shared chromatin-regulation network in stem-cell–derived human cortex
science2 months ago

Diverse autism mutations converge on a shared chromatin-regulation network in stem-cell–derived human cortex

A large hiPSC-based study generated cortical organoids from eight ASD-risk mutations, idiopathic ASD, and controls, profiling gene expression across 25–100 days. Early mutation-specific changes give way to convergent transcriptional and chromatin-regulatory disruptions enriched for ASD risk genes, including SWI–SNF components. CRISPRi validation supports key regulators driving this convergent network, suggesting that diverse genetic risks in ASD propagate through shared transcriptional pathways that affect early neurodevelopment, while idiopathic cases show less convergence.

via Nature|
#autism#crispr#ipsc
CRISPR breakthrough activates genes without DNA cuts
science3 months ago

CRISPR breakthrough activates genes without DNA cuts

Scientists at UNSW Sydney have developed a new CRISPR-based epigenetic editing technique that can turn genes on without cutting DNA, by removing chemical methyl groups that silence genes. This approach could lead to safer gene therapies for conditions like Sickle Cell disease, as it avoids the risks associated with DNA strand breaks. The research demonstrates that methylation directly controls gene activity and opens new possibilities for treating genetic disorders by reactivating silenced genes.

via ScienceDaily|
#crispr#dna-methylation#epigenetic-editing
CRISPR Innovation Promises New Era in Genetic Disease Therapy
science3 months ago

CRISPR Innovation Promises New Era in Genetic Disease Therapy

Researchers at UNSW Sydney have developed a safer CRISPR-based epigenetic editing technique that can switch genes on and off without cutting DNA, offering promising new treatments for genetic diseases like Sickle Cell by reactivating silenced genes through removal of methyl groups, potentially reducing risks associated with traditional gene editing.

via SciTechDaily|
#crispr#dna-methylation#epigenetic-editing