Single CAR-T dose neutralizes rare trio of autoimmune diseases
TL;DR Summary
A 47-year-old woman with three autoimmune diseases caused by B-cell antibodies—autoimmune hemolytic anemia, immune thrombocytopenia, and antiphospholipid syndrome—was treated with a single dose of engineered CAR-T cells after failing multiple therapies. Following targeted conditioning chemotherapy, her blood counts normalized within a month, and 14 months later she remains symptom-free and off all medications, suggesting CAR-T therapy could offer a one-off cure for some autoimmune conditions, though this is a single case and long-term safety and applicability need further study.
- One woman, three autoimmune diseases: CAR-T therapy vanquishes ultra-rare disease trio Nature
- Woman with three deadly diseases has ‘remarkable’ recovery after cell therapy The Guardian
- Woman With 3 Autoimmune Diseases Enters Remission After Immune 'Reset' ScienceAlert
- Scientists Are Finally Unlocking a Cancer Treatment’s Full Potential The Atlantic
- CAR T-cell therapy takes woman from bedridden to 'perfectly fine' New Scientist
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