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Car T Therapy

All articles tagged with #car t therapy

Biohacker Bryan Johnson spotlights autoimmune gastritis
health2 days ago

Biohacker Bryan Johnson spotlights autoimmune gastritis

Entrepreneur Bryan Johnson revealed he has autoimmune gastritis, a hard-to-diagnose autoimmune attack on stomach acid–producing cells that can cause iron deficiency, anemia, and increased cancer risk. Medical experts urge more biopsies for iron-deficient patients to catch the condition, while Johnson weighs treatment options including iron supplementation and experimental approaches like CAR-T therapy, underscoring that even intense health optimization can’t fully shield someone from disease.

via STAT|
#autoimmune-gastritis#car-t-therapy#colonoscopy
One-time CAR-T therapy Carvykti reshapes myeloma care and biotech leadership
health1 month ago

One-time CAR-T therapy Carvykti reshapes myeloma care and biotech leadership

Multiple myeloma, a brutal blood cancer, is increasingly treatable thanks to CAR-T immunotherapy, especially Carvykti, a BCMA-targeting one-time infusion that has produced durable remissions and in some cases cures. Developed in China and licensed to a Western company, Carvykti’s success—with CARTITUDE-1 showing a 76% response rate and five-year data indicating about 33% disease-free—highlights a shift in biotech leadership from the US to China, driven by faster early-stage trials and regulatory reforms. The US still dominates late-stage development, but China’s rapid trial ecosystem is accelerating the global pipeline, potentially enabling earlier, even first-line, use of such therapies and signaling a broad realignment in drug discovery and approval.

via Works in Progress Magazine|
#bcma#biotech-regulatory-reform#car-t-therapy
CAR-T Reset Reboots Immune System to Heal Three Autoimmune Diseases
health3 months ago

CAR-T Reset Reboots Immune System to Heal Three Autoimmune Diseases

A 47-year-old German woman with refractory autoimmune hemolytic anemia, immune thrombocytopenia, and antiphospholipid syndrome was treated with CAR-T cell therapy to eradicate rogue B cells and reboot her immune system. After exhausting standard therapies, this radical approach led to dramatic improvement and is described by doctors as a landmark in immunotherapy.

via ZME Science|
#aiha#aps#autoimmune-diseases
Single CAR-T dose neutralizes rare trio of autoimmune diseases
science3 months ago

Single CAR-T dose neutralizes rare trio of autoimmune diseases

A 47-year-old woman with three autoimmune diseases caused by B-cell antibodies—autoimmune hemolytic anemia, immune thrombocytopenia, and antiphospholipid syndrome—was treated with a single dose of engineered CAR-T cells after failing multiple therapies. Following targeted conditioning chemotherapy, her blood counts normalized within a month, and 14 months later she remains symptom-free and off all medications, suggesting CAR-T therapy could offer a one-off cure for some autoimmune conditions, though this is a single case and long-term safety and applicability need further study.

via Nature|
#autoimmunity#b-cells#car-t-therapy
Engineered T cells reduce Alzheimer's plaques in mice, a first for neurodegenerative disease
health3 months ago

Engineered T cells reduce Alzheimer's plaques in mice, a first for neurodegenerative disease

Washington University researchers used CAR-T cell therapy to reprogram brain immune cells to recognize and clear amyloid beta plaques in mice, reducing plaques and dampening neuroinflammation. This is the first application of CAR-T to a neurodegenerative disease, but it is early-stage and not yet ready for humans; scientists plan safety and dosing studies and will explore translation to other disorders, with potential relevance for veterans at risk of dementia.

via Military.com|
#alzheimers-disease#amyloid-beta#car-t-therapy
CAR-T Therapy for MS Aims to Target Brain B Cells to Slow Disease
health3 months ago

CAR-T Therapy for MS Aims to Target Brain B Cells to Slow Disease

U.S. researchers are testing CAR-T therapy—reprogramming a patient’s own T cells to attack overactive B cells implicated in MS—to see if it can reach the brain and slow progression. Early, small trials (including four MS patients at the Cleveland Clinic) show uncertain outcomes and potential risks like cytokine release syndrome and neurotoxicity, with experts cautioning that this approach is highly experimental and may not be more effective than existing MS drugs. Still, findings could improve understanding of MS and guide future therapies, even if not curative.

via NBC News|
#b-cells#car-t-therapy#clinical-trials
CAR-astrocytes: engineered brain cells purge Alzheimer's plaques in mice with one injection
science4 months ago

CAR-astrocytes: engineered brain cells purge Alzheimer's plaques in mice with one injection

Researchers engineered astrocytes to express a CAR targeting amyloid beta, turning them into brain “super cleaners.” In mice, a single gene-therapy injection either prevented plaque formation when given early or reduced existing amyloid plaques by ~50%, signaling a potential new immunotherapy approach for Alzheimer's—though safety and human trials remain to be established.

via ScienceAlert|
#alzheimers-disease#amyloid-beta#astrocytes