Stabilizing an anti-inflammatory protein boosts strength in aging mice

In aging mice, boosting the expression of the protein tristetraprolin (TTP) reduced frailty and improved physical performance—grip strength, walking speed, endurance—and bone density, with stronger effects in males. While not a human therapy and no trials are underway, the work reinforces the role of chronic inflammation in aging and suggests TTP as a promising target for interventions to preserve mobility and independence, potentially via pharmacological methods to stabilize TTP or modulate its signaling.