Tag

Mice

All articles tagged with #mice

science16 hours ago•8 min saved

Single-Dose Frog-Derived Bacterium Trims Tumors Completely in Mice

A bacterium isolated from frog gut, Ewingella americana, was given intravenously to mice with colorectal cancer and achieved a 100% complete tumor remission by both directly killing cancer cells and activating an anti-tumor immune response, outperforming some conventional therapies in this model; the bacterium selectively accumulates in tumors, clears rapidly from the bloodstream, and shows no lasting toxicity to healthy organs, suggesting a novel biodiversity-derived approach with potential for other cancers.

via SciTechDaily|

#bacteria #cancer #immunotherapy

health12 days ago•57 min saved

CBD and CBG Reprogram Liver Energy to Reverse Fatty Liver in Mice

Israeli researchers found that non-psychoactive cannabis compounds CBD and CBG can reverse liver damage in obese mice with MASLD by reprogramming liver energy use, boosting phosphocreatine reserves and lysosomal activity, and improving insulin resistance and lipid profiles. The treated mice showed reduced fat accumulation and inflammation without dietary changes, suggesting a new metabolic pathway to target in MASLD. However, these results are preclinical, and human relevance requires careful dosing considerations and clinical trials, as consumer CBD/CBG products vary in purity and concentration.

via Daily Mail|

#cbd #cbg #fatty-liver

health14 days ago•69 min saved

New gut microbe from Mediterranean diet shown to boost mouse strength

Researchers find that a Mediterranean-diet–associated gut bacterium, Roseburia inulinivorans, correlates with higher grip strength in humans and, when fed to mice, increases grip strength by about 30% over 4–8 weeks and shifts muscle fibers toward a stronger, fast-twitch type. The study suggests potential probiotic or drug approaches to combat frailty, but human trials are needed and delivering such an anaerobic microbe in pill form remains a hurdle; the work was published in Gut and underscores the gut-muscle connection.

via Live Science|

#gut-microbiome #health #mediterranean-diet

space15 days ago•4 min saved

Mice on the ISS Map a Path to Keeping Humans Fit on Mars

Researchers aboard the ISS exposed 24 mice to varying gravity levels (microgravity, 0.33 g, 0.67 g, and 1 g) to mimic Mars’ gravity, uncovering muscle changes and blood biomarkers that could help monitor astronauts’ muscle health on long Mars missions.

via The Daily Galaxy|

#biomarkers #gravity #mars

science16 days ago•6 min saved

One-shot SEAD1 therapy reverses schizophrenia-like brain issues in mice

Northwestern researchers found reduced Cacna2d1 protein in schizophrenia; they created a synthetic replacement, SEAD1, and showed that a single injection in mice with a schizophrenia-like genetic duplication normalized brain circuit activity and behavior, with no observed side effects. Human trials are planned but not yet underway.

via Boing Boing|

#cacna2d1 #mice #neuroscience

science17 days ago•6 min saved

Mouse cloning hits a genetic ceiling after 58 generations

Two decades, 58 generations and more than 30,000 cloning attempts show a single mouse cannot be serially recloned indefinitely: harmful DNA changes accumulate in the lineage, including chromosome losses, leading to a failure of later attempts and suggesting genome instability makes mammalian cloning unsustainable and potentially limits its use in agriculture and vertebrate breeding.

via Nature|

#cloning #genetics #mice

science24 days ago•4 min saved

Extreme Keto in Mice Reverses Hyperglycemia and Boosts Training Response

A mouse study found that an extreme ketogenic diet normalized high blood sugar in hyperglycemic mice within a week, and after eight weeks of diet plus exercise, they showed improved VO2peak and muscle oxidative capacity. However, real exercise performance only improved when carbohydrates were reintroduced, suggesting a complex diet–exercise interaction. The findings are limited to mice, with human trials planned, and researchers caution that such extreme dieting isn’t suitable for everyone while Mediterranean-style approaches may be better for blood-sugar control.

via ScienceAlert|

#blood-sugar #diabetes #exercise

science25 days ago•7 min saved

Matcha Quiets Sneezes by Targeting the Brain, Mouse Study Finds

A Hiroshima University study in mice finds that regular matcha intake reduces sneezing caused by allergen exposure by dampening brainstem activity linked to the sneezing reflex, without significantly changing immune markers like IgE, mast cells, or T cells—hinting at a brain-mediated, diet-based approach to managing allergic rhinitis; human studies are planned to confirm applicability.

via SciTechDaily|

#allergic-rhinitis #brain #matcha

science1 month ago•5 min saved

Older gut microbes unexpectedly rejuvenate ovaries in young mice

USC researchers found that fecal transplants from older mice into young, germ-free mice improved ovarian health and accelerated pup production, challenging the assumption that older microbiomes harm youth. The results suggest greater gut microbial diversity or altered estrogen signaling as potential mechanisms, but the exact reasons and relevance to humans remain unknown.

via ScienceAlert|

#aging #fertility #mice

science1 month ago•8 min saved

Keto Diet Could Boost Exercise Benefits in Hyperglycemic Mice

A Nature Communications study in mice with high blood sugar found that a ketogenic diet lowered glucose, improved aerobic exercise adaptation, and aided skeletal-muscle remodeling when paired with training, suggesting glucose control may enhance exercise benefits. However, results are limited to animals, and applicability to humans is uncertain, with long-term sustainability and real-world effects needing further research.

via Medical News Today|

#aerobic-capacity #exercise #hyperglycemia

animals1 month ago•18 min saved

Mice exhibit CPR-like care for distressed cage-mates, linked to oxytocin

A USC-led study observed mice performing first-aid–like behaviors toward an unconscious cage-mate—sniffing, grooming, and face-directed actions—triggered by unresponsiveness and strengthened by oxytocin signaling; responses are stronger for familiar cage-mates, suggesting an innate caregiving tendency that could aid group survival, though it is not human CPR.

via Earth.com|

#animals #first-aid #mice

science2 months ago•5 min saved

Tumors hijack brain signals through nerves to dampen immune defense

A Nature study in mice shows that lung cancer cells connect with nearby sensory neurons to send a signal to the brain that suppresses tumor-killing immune cells at the tumor site, allowing cancer to grow. Disabling these neurons reduced tumor growth by more than 50%, revealing a tumor-to-brain–immune axis that could be targeted to boost anticancer defenses.

via Nature|

#brain-tumor-signaling #immunology #lung-cancer

health2 months ago•261 min saved

Methionine may blunt severe illness in animal tests, study suggests

New animal research indicates the essential amino acid methionine, when added to the diet, can protect against severe illness by dampening inflammation and improving kidney function in mice with infection-induced inflammation. The study found methionine boosted kidney filtration and reduced inflammatory damage without weakening the immune response. While researchers see potential for broader use in inflammatory diseases, results are early and human relevance is not yet established, warranting further investigation.

via AOL.com|

#health #inflammation #kidneys

health2 months ago•6 min saved

Mice Reversal of Advanced Alzheimer's Sparks Hope for Humans

A study from University Hospitals, Case Western Reserve University, and the Cleveland VA reversed advanced Alzheimer's in mice by stabilizing brain NAD+ energy balance with the compound P7C3-A20, achieving full cognitive recovery and suggesting a potential amyloid-independent therapy for humans. While promising, results in animals don’t guarantee human success; the team aims for phase I safety trials within about 18 months and envisions broader use for neurodegeneration, alongside lifestyle measures and caregiver support.

via WKYC|

#alzheimers #clinicaltrials #health

science2 months ago•5 min saved

Sepsis-Protective Gene Turns Harmful in Older Mice

A Nature study in mice shows that a gene that helps young organisms survive sepsis can increase mortality in older mice, suggesting ageing rewires how the body tolerates infection and could guide age-specific therapies.

via Nature|

#ageing #immunity #infection