All articles tagged with #inflammaging
Scientists increased levels of the anti-inflammatory protein tristetraprolin (TTP) in 22‑month‑old mice, improving grip strength, mobility, endurance, energy, and bone health while reducing frailty; results suggest potential future therapies for aging but human applications are not imminent, with further work planned on neuroinflammation and dementia.
A Nature Aging study identifies a distinct population of p21+ Trem2+ senescent macrophages as major drivers of inflammaging. These cells exhibit a SASP and type I interferon signaling driven in part by cytosolic mitochondrial DNA, accumulate in aging livers and in metabolic dysfunction-associated steatotic liver disease (MASLD), and are distinct from classic M1/M2 macrophages. In both mouse models and human tissue, senolytic treatment with ABT-263 reduces liver inflammation and steatosis, supporting macrophage senescence as a tractable target for aging-related liver disease.
Researchers stabilized the inflammation-regulating protein tristetraprolin (TTP) in aged mice, reducing frailty and improving bone strength and immune health, suggesting that enhancing TTP could slow aging-related decline in humans, though therapies are years away and require more research.
A USC Leonard Davis School of Gerontology study analyzing the Health and Retirement Study (about 3,800 people aged 70+ in 2016) found that those who received the shingles vaccine had slower biological aging on several measures—lower inflammation and slower epigenetic and transcriptomic aging—than unvaccinated peers, suggesting vaccines may influence aging beyond preventing shingles, with effects lasting at least four years after vaccination; the results show an association, not causation.
Italian researchers analyzed DNA from over 1,000 individuals and found that centenarians carry more Western Hunter-Gatherer DNA, particularly the Villabruna cluster from about 14,000 years ago, which is linked to immune response and cellular repair. In a comparison of 333 centenarians and 690 younger adults, those with hunter-gatherer ancestry had about 38% higher odds of living to 100+, with the signal strongest in women. The study suggests ancient genomic patterns may influence aging and inflammaging, though environment and healthcare remain important and further lab work is needed to confirm functional effects.
A Columbia University study challenges the idea that chronic inflammation is a universal sign of aging, suggesting instead that it may be largely influenced by modern lifestyles and environmental factors, with significant differences observed between industrialized and Indigenous populations, and highlighting the need for context-aware health assessments.
A new study challenges the idea that inflammation universally increases with age, showing that in traditional societies like the Tsimane and Orang Asli, inflammation levels do not rise with age and are not linked to age-related diseases, suggesting that inflammaging may be a result of modern lifestyles rather than a universal aging process.
A study comparing different populations worldwide suggests that chronic inflammation, traditionally linked to ageing and age-related diseases, may not be a universal biological process but rather influenced by lifestyle and environment, challenging existing notions of inflammaging.
A new study challenges the traditional view that chronic inflammation, or inflammaging, is an inevitable part of aging, suggesting instead that diet, lifestyle, and environment play more significant roles, as evidenced by differences between industrialized and nonindustrialized populations. However, experts caution that further research is needed before revising current understanding.
A new study finds that aging-related inflammation, or 'inflammaging,' is not universal across human populations and is heavily influenced by environmental and lifestyle factors, with indigenous groups showing high inflammation levels driven by infection rather than age, challenging the idea that inflammation is a universal marker of aging.
A study from Columbia University suggests that age-related inflammation, or 'inflammaging,' is not universal and is influenced by lifestyle and environmental factors, with indigenous populations showing high inflammation levels driven by infections rather than aging, challenging the idea that inflammation is inherently linked to aging and chronic disease.
Menopause expert Dr. Mary Claire Haver emphasizes the impact of inflammaging on weight gain and health issues in women over 50, attributing it to chronic irritation in cells. She recommends anti-inflammatory foods, intermittent fasting, and turmeric consumption to combat inflammaging and aid weight loss. Success stories from her patients highlight the effectiveness of her approach, with women reporting significant weight loss and improved overall well-being by following her anti-inflammaging shortcuts.
As people age, changes in the gut microbiome can lead to inflammaging, a state of chronic low-level inflammation throughout the body. This imbalance in gut bacteria can compromise the intestinal barrier, leading to a decrease in immune responses and an increased risk of infection and disease. Factors such as diet, probiotics, and prebiotics play a crucial role in maintaining a healthy gut microbiome and supporting the immune system as people grow older.
Researchers at RIKEN have discovered that a deficiency of the signaling molecule RIPK1 in T cells can lead to premature aging symptoms and chronic inflammation, known as "inflammaging." This deficiency causes overactivation of cell-growth regulator mTORC1 by caspase-8 and RIPK3, resulting in T cell senescence. The study suggests that targeting caspase-8 and RIPK3 could potentially counteract inflammaging induced by T cell senescence, offering new treatment strategies for age-related diseases. Additionally, the researchers found that senescent T cells can revert to a normal state in a different environment, highlighting the role of environmental factors in regulating T cell senescence.