Tag

Inflammaging

All articles tagged with #inflammaging

science1 month ago•6 min saved

Stabilizing an anti-inflammatory protein boosts strength in aging mice

In aging mice, boosting the expression of the protein tristetraprolin (TTP) reduced frailty and improved physical performance—grip strength, walking speed, endurance—and bone density, with stronger effects in males. While not a human therapy and no trials are underway, the work reinforces the role of chronic inflammation in aging and suggests TTP as a promising target for interventions to preserve mobility and independence, potentially via pharmacological methods to stabilize TTP or modulate its signaling.

via ScienceAlert|

#aging #frailty #inflammaging

health-and-medicine1 month ago•7 min saved

Boosting a protective protein slows aging frailty and strengthens bones in mice

Scientists increased levels of the anti-inflammatory protein tristetraprolin (TTP) in 22‑month‑old mice, improving grip strength, mobility, endurance, energy, and bone health while reducing frailty; results suggest potential future therapies for aging but human applications are not imminent, with further work planned on neuroinflammation and dementia.

via ScienceDaily|

#aging #bone-health #frailty

science2 months ago•98 min saved

p21+TREM2+ Senescent Macrophages Drive Inflammaging and MASLD, Reversed by Senolytics

A Nature Aging study identifies a distinct population of p21+ Trem2+ senescent macrophages as major drivers of inflammaging. These cells exhibit a SASP and type I interferon signaling driven in part by cytosolic mitochondrial DNA, accumulate in aging livers and in metabolic dysfunction-associated steatotic liver disease (MASLD), and are distinct from classic M1/M2 macrophages. In both mouse models and human tissue, senolytic treatment with ABT-263 reduces liver inflammation and steatosis, supporting macrophage senescence as a tractable target for aging-related liver disease.

via Nature|

#inflammaging #masld #p21

science3 months ago•9 min saved

Stabilizing an Inflammation-Regulating Protein Slows Aging-Related Frailty in Mice

Researchers stabilized the inflammation-regulating protein tristetraprolin (TTP) in aged mice, reducing frailty and improving bone strength and immune health, suggesting that enhancing TTP could slow aging-related decline in humans, though therapies are years away and require more research.

via SciTechDaily|

#aging #bone-health #frailty

health5 months ago•7 min saved

Shingles Shot May Slow the Body's Aging Clock, USC Study Finds

A USC Leonard Davis School of Gerontology study analyzing the Health and Retirement Study (about 3,800 people aged 70+ in 2016) found that those who received the shingles vaccine had slower biological aging on several measures—lower inflammation and slower epigenetic and transcriptomic aging—than unvaccinated peers, suggesting vaccines may influence aging beyond preventing shingles, with effects lasting at least four years after vaccination; the results show an association, not causation.

via SciTechDaily|

#aging #epigenetic-aging #health

science6 months ago•5 min saved

Ice-Age DNA Linked to Living Past 100, Italian Study Finds

Italian researchers analyzed DNA from over 1,000 individuals and found that centenarians carry more Western Hunter-Gatherer DNA, particularly the Villabruna cluster from about 14,000 years ago, which is linked to immune response and cellular repair. In a comparison of 333 centenarians and 690 younger adults, those with hunter-gatherer ancestry had about 38% higher odds of living to 100+, with the signal strongest in women. The study suggests ancient genomic patterns may influence aging and inflammaging, though environment and healthcare remain important and further lab work is needed to confirm functional effects.

via Indian Defence Review|

#centenarians #hunter-gatherer-ancestry #inflammaging

science1 year ago•3 min saved

Rethinking Aging: New Perspectives on Inflammation and Lifestyle

A Columbia University study challenges the idea that chronic inflammation is a universal sign of aging, suggesting instead that it may be largely influenced by modern lifestyles and environmental factors, with significant differences observed between industrialized and Indigenous populations, and highlighting the need for context-aware health assessments.

via SciTechDaily|

#aging #indigenous-populations #inflammaging

science1 year ago•4 min saved

New Research Challenges Universal Views on Aging and Inflammation

A new study challenges the idea that inflammation universally increases with age, showing that in traditional societies like the Tsimane and Orang Asli, inflammation levels do not rise with age and are not linked to age-related diseases, suggesting that inflammaging may be a result of modern lifestyles rather than a universal aging process.

via ScienceAlert|

#aging #health #indigenous-populations

science1 year ago•4 min saved

Challenging Assumptions: Inflammation and Aging Vary Across Populations

A study comparing different populations worldwide suggests that chronic inflammation, traditionally linked to ageing and age-related diseases, may not be a universal biological process but rather influenced by lifestyle and environment, challenging existing notions of inflammaging.

via The Conversation|

#ageing #indigenous-populations #inflammaging

health1 year ago•2 min saved

New research challenges universal beliefs about aging and inflammation

A new study challenges the traditional view that chronic inflammation, or inflammaging, is an inevitable part of aging, suggesting instead that diet, lifestyle, and environment play more significant roles, as evidenced by differences between industrialized and nonindustrialized populations. However, experts caution that further research is needed before revising current understanding.

via The Independent|

#aging #health #inflammaging

health1 year ago•3 min saved

Study Challenges Universal Link Between Aging and Inflammation

A new study finds that aging-related inflammation, or 'inflammaging,' is not universal across human populations and is heavily influenced by environmental and lifestyle factors, with indigenous groups showing high inflammation levels driven by infection rather than age, challenging the idea that inflammation is a universal marker of aging.

via Medical Xpress|

#aging #health #immune-system

science1 year ago•3 min saved

Study Challenges Universal Link Between Aging and Inflammation

A study from Columbia University suggests that age-related inflammation, or 'inflammaging,' is not universal and is influenced by lifestyle and environmental factors, with indigenous populations showing high inflammation levels driven by infections rather than aging, challenging the idea that inflammation is inherently linked to aging and chronic disease.

via Columbia University Mailman School of Public Health|

#aging #health-disparities #indigenous-populations

health-and-wellness2 years ago•7 min saved

"Menopause Weight Loss: Top Foods for Beating Inflammaging"

Menopause expert Dr. Mary Claire Haver emphasizes the impact of inflammaging on weight gain and health issues in women over 50, attributing it to chronic irritation in cells. She recommends anti-inflammatory foods, intermittent fasting, and turmeric consumption to combat inflammaging and aid weight loss. Success stories from her patients highlight the effectiveness of her approach, with women reporting significant weight loss and improved overall well-being by following her anti-inflammaging shortcuts.

via Woman's World|

#anti-inflammatory-foods #dr-mary-claire-haver #health-and-wellness

health2 years ago•5 min saved

"The Impact of Aging on Gut Health and Inflammaging"

As people age, changes in the gut microbiome can lead to inflammaging, a state of chronic low-level inflammation throughout the body. This imbalance in gut bacteria can compromise the intestinal barrier, leading to a decrease in immune responses and an increased risk of infection and disease. Factors such as diet, probiotics, and prebiotics play a crucial role in maintaining a healthy gut microbiome and supporting the immune system as people grow older.

via The Conversation|

#aging #gut-microbiome #health

health3 years ago•2 min saved

Unraveling the Link Between RIPK1 Deficiency and Aging Inflammation

Researchers at RIKEN have discovered that a deficiency of the signaling molecule RIPK1 in T cells can lead to premature aging symptoms and chronic inflammation, known as "inflammaging." This deficiency causes overactivation of cell-growth regulator mTORC1 by caspase-8 and RIPK3, resulting in T cell senescence. The study suggests that targeting caspase-8 and RIPK3 could potentially counteract inflammaging induced by T cell senescence, offering new treatment strategies for age-related diseases. Additionally, the researchers found that senescent T cells can revert to a normal state in a different environment, highlighting the role of environmental factors in regulating T cell senescence.

via SciTechDaily|

#aging #health #immune-system