Whole-Body Imaging Unmasks Real-Time Cellular Dialogue Across a Living Organism
TL;DR Summary
Researchers unveiled WHOLISTIC, a whole-organism live-imaging method that makes nearly every cell express fluorescent calcium sensors to watch real-time signaling across an entire body, first demonstrated in transparent zebrafish and Danionella cerebrum. The technique links brain, muscles, and organ systems in a single animal, reveals unexpected activity in cartilage cells and meninges, and promises a platform for studying physiology, neuroscience, and behavior across the body.
Topics:health#calcium-signaling#multi-organ-interactions#science#whole-organism#wholistic-imaging#zebrafish
- Scientists Can Now Watch 'Conversations' Between Cells Across The Body of a Living Animal ScienceAlert
- Imaging cellular activity across all organs reveals body-wide circuits Nature
- A ‘WHOLISTIC’ View of Cellular Communication Across an Entire Animal HHMI
- New imaging method reveals cellular activity across the whole zebrafish body UCL | University College London
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