Younger adults with older-looking biology linked to higher risk of early-onset cancers, study finds

A Nature Medicine study analyzed UK Biobank and All of Us data to estimate biological age (the gap between chronologic and biological aging) using aging clocks like PhenoAge and Klemera-D Doubal. It found that younger cohorts show larger age gaps and that those with older-appearing biology have a higher risk of early-onset cancers, especially lung, gastrointestinal and uterine cancers. The associations are correlational and may be influenced by calibration of aging tests or other exposures; results require replication and further validation before concluding a causal link between faster biological aging and early-onset cancer.