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5 Ht2a

All articles tagged with #5 ht2a

Psilocybin May Shield Nerves From Chemotherapy, Mouse Study Suggests
medicine-and-drugs1 month ago

Psilocybin May Shield Nerves From Chemotherapy, Mouse Study Suggests

A mouse study published in Science found that psilocybin, given before chemotherapy, can prevent chemotherapy-induced peripheral neuropathy by preserving mitochondrial trafficking and ATP production in nerve endings. The protective effect relies on the serotonin receptor 5-HT2A, and a non-hallucinogenic 5-HT2A activator also provided protection. Human trials have not yet proven efficacy, though researchers plan to move toward clinical testing.

Psilocybin’s 5-HT2A activation linked to lasting brain plasticity in mice
neuroscience6 months ago

Psilocybin’s 5-HT2A activation linked to lasting brain plasticity in mice

A mouse study shows psilocybin dose-dependently activates the brain’s 5-HT2A receptors in the prefrontal cortex, with an inverted-U relationship for acute behaviors. The following day, moderate doses reduced anxiety-like exploration and higher doses decreased depression-like immobility, coinciding with changes in microtubule dynamics and increased synaptic plasticity proteins—primarily in the prefrontal cortex, not the amygdala—suggesting a neural mechanism for lasting antidepressant effects, though results in animals may not directly translate to humans.