Ancient DNA Maps the Long Arc of Human Adaptation
Nature Genetics’ 2026 review synthesizes how ancient DNA enables direct observation of genetic changes over time, detailing how humans adapted to shifts in diet, mobility, pathogen exposure, and environment; it reviews methods for detecting selection in ancient genomes, assesses the impact of major migrations and admixture, links findings across continents and archaeological contexts, and outlines future challenges and opportunities for using ancient DNA to uncover adaptive insights that aren’t apparent from modern genomes alone.