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Agrp Neurons

All articles tagged with #agrp neurons

science2 hours ago•5 min saved

GLP-1 Weight Drugs May Weigh on Fat Use, Not Just Appetite

A new mouse study suggests long-term weight loss from GLP-1 drugs like Ozempic and Wegovy may rely not only on suppressing appetite but also on energy mobilization governed by AgRP hunger neurons. When these neurons were disrupted in female mice, semaglutide still reduced eating, but fat mobilization and the overall weight-loss effect weakened, leading to weight regain within about two weeks. Normal-functioning neurons maintained weight loss, and disruptions involving Sirt1 signaling partially reversed the effect. Results are preclinical and observed mainly in female mice, so more research is needed to understand implications for humans.

via ScienceAlert|

#agrp-neurons #glp-1 #mice-study

neuroscience3 years ago•3 min saved

The Brain's Role in Diet Outcomes and Weight Regain

Researchers from the Max Planck Institute for Metabolism Research and Harvard Medical School have found that communication in the brain changes during a diet, leading to stronger signals in the nerve cells that mediate the feeling of hunger. This may explain why people tend to eat more after a diet and regain the weight they have lost. The researchers were able to selectively inhibit the neural pathways in mice that activate AgRP neurons, leading to significantly less weight gain after the diet. The findings could help develop drugs to prevent this amplification and help maintain a reduced body weight after dieting.

via Neuroscience News|

#agrp-neurons #brain-changes #dieting