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Mice Study

All articles tagged with #mice study

Oral TOFA boosts fat burning and may preserve muscle in weight loss
health1 month ago

Oral TOFA boosts fat burning and may preserve muscle in weight loss

Researchers at UC Berkeley identified TOFA, an oral compound that reduced body weight in obese mice by about 18% by increasing energy expenditure rather than suppressing appetite, and it preserved lean mass; when paired with GLP-1 drugs such as semaglutide or tirzepatide, it produced greater weight loss and improved metabolic markers; TOFA also showed liver benefits in mouse models of fatty liver disease, without raising triglycerides. The effects in humans are unknown, the study involved only male mice, and questions remain about dosing, safety, and long-term risks before any human use.

via foxnews.com|
#energy-expenditure#health#mice-study
GLP-1 Weight Drugs May Weigh on Fat Use, Not Just Appetite
science1 month ago

GLP-1 Weight Drugs May Weigh on Fat Use, Not Just Appetite

A new mouse study suggests long-term weight loss from GLP-1 drugs like Ozempic and Wegovy may rely not only on suppressing appetite but also on energy mobilization governed by AgRP hunger neurons. When these neurons were disrupted in female mice, semaglutide still reduced eating, but fat mobilization and the overall weight-loss effect weakened, leading to weight regain within about two weeks. Normal-functioning neurons maintained weight loss, and disruptions involving Sirt1 signaling partially reversed the effect. Results are preclinical and observed mainly in female mice, so more research is needed to understand implications for humans.

via ScienceAlert|
#agrp-neurons#glp-1#mice-study
Sugar-Free Diet in Mice Triggers Hidden Metabolic Setbacks
science3 months ago

Sugar-Free Diet in Mice Triggers Hidden Metabolic Setbacks

A 16-week mouse study found that removing sucrose from a low-fat diet disrupted gut bacteria, reduced beneficial microbes, and led to metabolic problems—impaired glucose control, insulin resistance, and fat buildup in the liver—despite similar body weight. The researchers caution that the findings, presented at ENDO 2026 and awaiting peer review, don’t yet translate to humans and suggest that completely eliminating sugar may not always be beneficial, underscoring the need to balance carbohydrates and gut health.

via ScienceAlert|
#gut-microbiome#insulin-resistance#metabolic-health
Zero-sugar, low-fat diet triggers insulin resistance in mice
health3 months ago

Zero-sugar, low-fat diet triggers insulin resistance in mice

A 16-week study in mice found that a sugar-free, low-fat diet caused impaired glucose tolerance and reduced insulin sensitivity, with inflammation in the colon and liver and signs of fatty liver disease, despite similar weight gain to controls. The sugar-free group also showed gut microbiome changes, including lower levels of beneficial Lactobacillus murinus and higher inflammatory bacteria. Findings were presented at ENDO 2026 and have not yet undergone peer review; relevance to humans remains to be determined.

via Medical News Today|
#fatty-liver-disease#gut-microbiome#health
Sweeteners May Shape Metabolism Across Generations, Mouse Study Finds
health5 months ago

Sweeteners May Shape Metabolism Across Generations, Mouse Study Finds

A Frontiers in Nutrition study in mice suggests that feeding sucralose or stevia to one generation can trigger changes in metabolism-related genes and gut bacteria that persist in their offspring even when later generations consume no sweeteners, with stronger effects seen for sucralose and some male offspring showing impaired glucose regulation; though the results are not directly transferable to humans, researchers urge further study and moderation, while an industry group says safety remains unchanged.

via Fox News|
#artificial-sweeteners#gut-microbiome#health
Mice on Keto Diet Show Hidden Metabolic Trade-Offs
science8 months ago

Mice on Keto Diet Show Hidden Metabolic Trade-Offs

University of Utah researchers fed mice four diets for nine months; those on a keto-style high-fat, low-carb diet gained less weight than a Western high-fat diet but developed fatty liver and impaired liver function in males, with both sexes showing reduced blood glucose and insulin due to impaired pancreatic insulin production. The effects reversed after stopping the diet, but human relevance remains unproven, underscoring potential metabolic trade-offs of ketosis beyond epilepsy uses.

via ScienceAlert|
#fatty-liver#insulin-regulation#ketogenic-diet
Gaseous Molecule May Shield Brain Against Alzheimer's, Study in Mice Finds
science8 months ago

Gaseous Molecule May Shield Brain Against Alzheimer's, Study in Mice Finds

A Johns Hopkins-led lab study in genetically modified mice showed that slowly releasing hydrogen sulfide (the gas behind fart smells) with NaGYY improved memory and motor function by about 50% after 12 weeks, suggesting hydrogen sulfide signaling might slow neurodegeneration and could inform future Alzheimer’s therapies. Results are preclinical and limited to animal models, though researchers are now exploring the molecular pathways, including interactions with GSK3β, to understand potential human applications.

via Indian Defence Review|
#alzheimers-disease#gas-signaling#hydrogen-sulfide
Psilocybin Shows Promise as a Revolutionary Anti-Aging Treatment
science1 year ago

Psilocybin Shows Promise as a Revolutionary Anti-Aging Treatment

A groundbreaking study found that psilocybin not only extends lifespan in aging mice but also delays cellular aging in human cells, suggesting its potential as a treatment for age-related diseases and healthy aging. The research demonstrated increased survival rates, improved physical health, and cellular markers of reduced aging, though further studies are needed to confirm safety and efficacy in humans.

via PsyPost|
#anti-aging#cellular-lifespan#health-benefits