
Tirzepatide Might Trigger More Hair Loss Than Semaglutide, Early Study Suggests
A preprint study comparing tirzepatide (Zepbound/Mounjaro) with semaglutide (Ozempic/Wegovy) in 8,985 women found higher incident alopecia with tirzepatide (5.44% vs 3.63%). At six months, 1.55% vs 1.24%; at twelve months, 4.20% vs 2.88%. After adjusting for weight loss, hair loss remained more common with tirzepatide (4.24% vs 3.33%), suggesting weight loss alone doesn’t explain the difference. The study is observational and not yet peer‑reviewed. Experts note GLP-1 meds can cause temporary shedding, and persistent patches should be evaluated by a dermatologist; patients should not stop their medication without physician guidance. The differing receptor targets (GIP/GLP-1 for tirzepatide vs GLP-1 alone for semaglutide) may influence the hair follicle environment, but mechanisms are not yet clear.













