Tag

Antibody Design

All articles tagged with #antibody design

Pfizer Taps Chai Discovery to Fast-Track AI-Designed Biologics
technology1 month ago

Pfizer Taps Chai Discovery to Fast-Track AI-Designed Biologics

Chai Discovery announced a license with Pfizer to deploy its frontier AI platform, including the Chai-3 model and a Pfizer-custom model, within Pfizer’s drug discovery engine to accelerate biomolecule design and target hard-to-reach areas. Pfizer will gain early access to Chai-3, which advances antibody design and generalization, alongside a tailored model leveraging Pfizer’s data. The deal highlights growing use of AI in pharma to shorten discovery timelines that traditionally span months to weeks.

AI Advances in Antibody Design Accelerate Drug Development and Viral Defense
science8 months ago

AI Advances in Antibody Design Accelerate Drug Development and Viral Defense

The article discusses a novel computational approach using RFdiffusion, fine-tuned on antibody structures, to design de novo antibodies and VHHs with atomic-level accuracy, targeting specific epitopes. The method enables the creation of antibodies with precise epitope targeting, validated by cryo-EM structures, and demonstrates potential for rapid therapeutic development, although current success rates are low and can be improved with advanced filtering techniques like AlphaFold3.