Fat Cells Retain Epigenetic 'Memory' of Obesity, Driving Persistent Hunger and Weight Regain
New preclinical research suggests that obesity leaves a lasting epigenetic 'memory' in fat cells, keeping the hunger hormone asprosin elevated even after weight loss. This mechanism may explain why patients regain weight after stopping GLP-1 medications and why offspring of mothers with obesity face higher susceptibility. While the findings are based on mouse models, they identify a potential therapeutic target for preventing weight rebound.
