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Avidity Biosciences

All articles tagged with #avidity biosciences

Investor urges board overhaul as Novartis grapples with costly deal setbacks
business1 month ago

Investor urges board overhaul as Novartis grapples with costly deal setbacks

A top investor, Artisan Partners’ David Samra, is pressuring Novartis to overhaul its board and tighten dealmaking after the costly $12 billion Avidity Biosciences acquisition flop and recent phase-3 setbacks like pelacarsen, which sent shares down more than 10% and wiped about $30 billion from market value. Samra criticized the deal team and called for stronger scrutiny of future acquisitions, though he did not fault CEO Vas Narasimhan. Novartis defended its disciplined capital allocation and pipeline strength, noting some deals (e.g., Chinook’s Vanrafia) have paid off and reaffirmed its sales guidance.

Novartis DM1 drug flops in phase 3, clouding $12B Avidity deal
business1 month ago

Novartis DM1 drug flops in phase 3, clouding $12B Avidity deal

Novartis’ phase 3 Harbor trial of del-desiran failed to meet its primary endpoint in myotonic dystrophy type 1 (DM1), undermining the $12 billion acquisition of Avidity Biosciences and sending the stock lower in premarket trading. While some secondary signals were noted, the miss raises questions about del-desiran’s contribution to future sales; Novartis will review the full data with regulators to determine next steps. The company also continues with other Avidity assets—delpacibart zotadirsen for Duchenne and delpacibart braxlosiran for FSHD—pursuing next actions based on newer data and FDA discussions.

Atrium Therapeutics spins out from Novartis-Avidity deal with two cardio RNA therapies
business7 months ago

Atrium Therapeutics spins out from Novartis-Avidity deal with two cardio RNA therapies

Atrium Therapeutics, a spinout formed from Novartis's $12 billion acquisition of Avidity Biosciences, debuts with $270 million in cash and two preclinical RNA interference assets (ATR 1072 for PRKAG2 syndrome and ATR 1086 for PLN cardiomyopathy). Led by Kathleen Gallagher, Atrium plans a Phase 1 trial for ATR 1072 in the second half of this year and for ATR 1086 in 2027, with the new ticker RNAM, inheriting Avidity's market position.

Novartis to Acquire Avidity Biosciences for $12 Billion to Strengthen Neuroscience Pipeline
business11 months ago

Novartis to Acquire Avidity Biosciences for $12 Billion to Strengthen Neuroscience Pipeline

Novartis plans to acquire Avidity Biosciences for $12 billion to strengthen its neuroscience pipeline with late-stage RNA therapeutics targeting neuromuscular diseases, including a new platform for muscle-directed delivery of RNA therapies, aiming for product launches before 2030 and increasing its sales growth forecast to 6% CAGR for 2024-2029.