All articles tagged with #blood groups
Researchers mapped transcription-factor binding across 33 blood-group genes, uncovering regulatory switches that control antigen expression and explain why people with the same blood type can have different antigen levels. The Helgeson CR1 case shows how tiny DNA changes can reduce expression, affecting transfusion safety, and the approach could lead to more accurate blood typing and insight into malaria resistance.
Scientists at Lund University in Sweden have developed a toolbox that helps explain the variances in blood group molecule levels between individuals, solving a 50-year-old mystery related to blood transfusion safety. By studying transcription factors, the researchers identified genetic variations in landing sites that regulate the expression of blood group antigens. They applied this approach to understand the Helgeson blood group, which had remained unexplained for decades. The study not only improves blood group testing but also opens up possibilities for exploring the role of blood groups in diseases. The researchers aim to update existing DNA-based tests to include the newly discovered variant, making blood transfusions safer.