Protective Brain Microglia Rise with Alzheimer's Progression, Study Finds
An unprecedented analysis of over 830,000 brain immune cells from 1,607 donors identified a disease-associated microglia subtype that expands as Alzheimer's progresses and relies on the TREM2-MITF-GPNMB pathway to clear harmful material, suggesting therapies should bolster the brain’s natural immune defenses rather than focus solely on amyloid plaques.