Protective Brain Microglia Rise with Alzheimer's Progression, Study Finds
TL;DR Summary
An unprecedented analysis of over 830,000 brain immune cells from 1,607 donors identified a disease-associated microglia subtype that expands as Alzheimer's progresses and relies on the TREM2-MITF-GPNMB pathway to clear harmful material, suggesting therapies should bolster the brain’s natural immune defenses rather than focus solely on amyloid plaques.
- Study of Brain Immune Cells Reveals New Clues to Alzheimer’s Disease Progression Neuroscience News
- Immune cells cross blood-brain barrier during human aging National Institutes of Health (NIH) | (.gov)
- Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer’s disease Nature
- Scientists discover a hidden brain shift that begins around age 50 ScienceDaily
- Protein secreted by immune cells may help drive brain aging Medical Xpress
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