All articles tagged with #cardiometabolic disease
A Nature study of over a million people found rare, protein-truncating FNIP1 mutations that lift a cellular energy brake, nudging the body to burn fat, improve fat distribution, and cut cardiometabolic disease risk by about 60%; lab and mouse experiments support the mechanism, suggesting FNIP1 as a potential drug target, though safety and efficacy of inhibiting FNIP1 are not yet proven.
A large genomics study of over one million people links certain FNIP1 gene variants to more muscle, less belly fat, better glucose metabolism and a substantially lower risk of cardiometabolic diseases such as type 2 diabetes and heart disease, suggesting FNIP1 as a potential target for future therapies.
Time-restricted eating (TRE) could reduce the risks of heart disease linked with shift work, according to a new study. Firefighters who followed a time-restricted eating plan, eating all of their meals within a 10-hour time window, saw those risks reduced. The intervention focused on firefighters in San Diego, California, and provided benefits to participants who had indications of cardiometabolic disease. The research team wants to conduct similar studies with healthcare workers.