Tag

Cardiometabolic Disease

All articles tagged with #cardiometabolic disease

pharmaceuticals1 month ago•0 min saved

Novo Nordisk Signs $1.4B Deal with Orbis Medicines for Oral Cardiometabolic Drugs

Novo Nordisk has agreed to a collaboration with Copenhagen-based biotech Orbis Medicines, involving total payments of up to $1.4 billion. The partnership focuses on developing orally bioavailable macrocycle therapies for cardiometabolic diseases, aiming to replace injectable treatments. This deal represents Orbis's first major pharma partnership and comes as Novo seeks to diversify its pipeline following recent setbacks in its GLP-1 and inflammation drug programs.

via Fierce Biotech|

#cardiometabolic-disease #drug-development #macrocycles

health-and-science2 months ago•3 min saved

Brief Sprints Trigger Massive Blood Protein Shifts Linked to Metabolic Health

A study from Rockefeller University reveals that just three minutes of intense sprinting alters nearly 25% of blood proteins and over 200 metabolites, a response far exceeding that of 90 minutes of moderate cycling. These rapid molecular changes, driven by a process called ectodomain shedding, correlate with lower risks of obesity, type 2 diabetes, and cardiovascular disease in large population data. While moderate exercise produces slower, smaller shifts, the findings suggest high-intensity bursts uniquely activate protective signaling pathways, though experts caution that this does not replace the benefits of regular, sustained physical activity.

via Science Daily|

#cardiometabolic-disease #exercise-physiology #health-and-science

science2 months ago•5 min saved

FNIP1 gene variant reshapes body fat and muscle, lowering cardiometabolic risk

A large genomics study of over one million people links certain FNIP1 gene variants to more muscle, less belly fat, better glucose metabolism and a substantially lower risk of cardiometabolic diseases such as type 2 diabetes and heart disease, suggesting FNIP1 as a potential target for future therapies.

via Nature|

#cardiometabolic-disease #fnip1 #genetics

health3 years ago•3 min saved

Time-Restricted Eating for Work-Related Health Prevention.

Time-restricted eating (TRE) could reduce the risks of heart disease linked with shift work, according to a new study. Firefighters who followed a time-restricted eating plan, eating all of their meals within a 10-hour time window, saw those risks reduced. The intervention focused on firefighters in San Diego, California, and provided benefits to participants who had indications of cardiometabolic disease. The research team wants to conduct similar studies with healthcare workers.

via Good News Network|

#cardiometabolic-disease #firefighters #health