Peripheral dendritic cell priming drives CD8+ T cell–mediated tau neurodegeneration
A tauopathy mouse study shows conventional dendritic cell 1 (cDC1)–dependent cross-presentation of brain-derived antigens in peripheral lymphoid tissues primes CD8+ T cells that infiltrate the brain and worsen tau-related neurodegeneration; removing cDC1s or disrupting cross-presentation protects against neuronal loss and reduces brain T cell accumulation, highlighting a peripheral brain–immune axis as a potential therapeutic target.