Peripheral dendritic cell priming drives CD8+ T cell–mediated tau neurodegeneration
TL;DR Summary
A tauopathy mouse study shows conventional dendritic cell 1 (cDC1)–dependent cross-presentation of brain-derived antigens in peripheral lymphoid tissues primes CD8+ T cells that infiltrate the brain and worsen tau-related neurodegeneration; removing cDC1s or disrupting cross-presentation protects against neuronal loss and reduces brain T cell accumulation, highlighting a peripheral brain–immune axis as a potential therapeutic target.
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- Removing T cells prevents Alzheimer's brain damage courthousenews.com
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- Immune Cells Driving Alzheimer’s-Like Neurodegeneration Traced to Lymph Nodes Genetic Engineering and Biotechnology News
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