
Stem-Cell Patch Rebuilds Cornea, Boosts Vision in Rare Eye Disorder
A JAMA Ophthalmology study reports RAFT-OS, a collagen scaffold graft that combines surface stem cells with healthy stromal keratocytes to treat aniridia-related keratopathy. Transplanted to one eye, this approach addresses the damaged environment needed for stem cells to survive. By 3 months, five of nine treated eyes had fully normalized corneal surfaces; by 12 months, treated eyes showed dramatic surface improvement while untreated eyes did not. Participants gained nearly five lines on the ETDRS chart. The technique could enable further treatments and be applied to other severe corneal surface diseases, but larger, longer-term trials and cost/regulatory hurdles remain.



