3D Imaging Reveals How Killer T Cells Attack Cancer Inside Tumors
Researchers used cryo-expansion microscopy to preserve near-native cell structure and visualize cytotoxic T lymphocytes at the immune synapse in 3D, revealing a dome-shaped contact interface and variations in cytotoxic granules. Extending the technique to human tumor tissues, the team could observe T cells infiltrating tumors and deploying their killing machinery at nanometer-scale resolution, offering insights that could guide improvements in immuno-oncology therapies.
