All articles tagged with #cytotoxic t cells
Scientists used cryo-expansion microscopy to visualize, in 3D and near-native conditions, how cytotoxic T lymphocytes form an immune synapse and destroy cancer cells with high precision—revealing a dome-shaped contact and granular cores—and extended the method to human tumor tissues to inform immuno-oncology.
Researchers isolated authentic reservoir clones that proliferate and produce infectious HIV under ART, with only small fractions expressing viral proteins at any moment. Prolonged exposure to a CD8+ cytotoxic T-lymphocyte (CTL) clone substantially reduces these clones, showing time-integrated vulnerability to immune pressure, though some ARC exhibit cell-intrinsic resistance linked to low oxidative stress, which can be reversed with deferoxamine. The findings highlight specific immune-escape pathways as targets to enhance HIV cure strategies.