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Dana Farber

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Rare EGFR Mutation Linked to 62-Fold Lung Cancer Risk in Never-Smokers
health15 days ago

Rare EGFR Mutation Linked to 62-Fold Lung Cancer Risk in Never-Smokers

A new study in Science identifies a rare inherited EGFR T790M mutation that dramatically increases lung cancer risk, particularly among never-smokers. Researchers found that carriers face 62 times the odds of developing the disease compared to non-carriers who have never smoked, and 25 times the odds overall. The mutation is rare nationwide but significantly more prevalent in Southern Appalachia due to a historical founder effect. While the study does not prove that genetic testing improves outcomes, it suggests future screening could be based on inherited risk rather than just smoking history.

via Fox News|
#23andme#dana-farber#egfr-t790m
Rare Genetic Mutation Identified as Major Lung Cancer Risk Factor for Non-Smokers
health16 days ago

Rare Genetic Mutation Identified as Major Lung Cancer Risk Factor for Non-Smokers

A rare inherited mutation in the EGFR gene, known as T790M, has been identified as a significant risk factor for lung cancer, particularly among non-smokers. A large-scale study involving over 3.3 million individuals found that carriers of this mutation have a 62-fold higher risk of developing lung cancer if they have never smoked, and a 25-fold higher risk overall. The mutation is rare, affecting approximately 1 in 15,850 people, and is most prevalent in populations with Southern Appalachian ancestry. Researchers suggest that genetic testing could lead to earlier screening and detection for at-risk individuals.

via New York Post|
#23andme#dana-farber#egfr-t790m
Cancer-care shakeup: Dana-Farber exits MGB’s Medicare Advantage network
business1 month ago

Cancer-care shakeup: Dana-Farber exits MGB’s Medicare Advantage network

Mass General Brigham Health Plan will drop Dana-Farber Cancer Institute from its Medicare Advantage network starting Oct. 1, a move tied to financial pressures amid a broader split between Dana-Farber and MGB. About 20,500 plan members are affected, though only a fraction currently receive Dana-Farber care; roughly 250 members are actively treated there and up to 1,000 had appointments this year. Dana-Farber says it’s the first time a health insurer has removed it from a network and notes patients can stay in-network for up to 90 days or through the end of ongoing treatment, while offering financial counseling and alternative plan options. Dana-Farber is pursuing a new cancer-hospital partnership with Beth Israel Lahey Health, and MGB is investing in its own cancer institute, highlighting the broader “cancer wars” and the use of narrow networks to control costs.

via The Boston Globe|
#business#cancer-care#dana-farber
New survivorship programs expand cancer aftercare across New England
healthcare3 months ago

New survivorship programs expand cancer aftercare across New England

Hospitals across New England, led by Dana-Farber, Mass General Brigham, UMass Memorial Health and Dartmouth, are expanding survivorship services to help patients navigate lingering physical and emotional effects and financial debt after cancer treatment, offering survivorship care plans, counseling, family planning, and financial guidance as survival improves.

via The Boston Globe|
#cancer-survivorship#dana-farber#healthcare
MGB and Dana-Farber expand early cancer detection amid cost and value questions
business5 months ago

MGB and Dana-Farber expand early cancer detection amid cost and value questions

Mass General Brigham and Dana-Farber are expanding early cancer-detection programs, including genetic testing and blood-based screenings, as they push prevention and early intervention even as the institutions’ looming split raises questions about value, cost, and patient anxiety; experts caution that not all tests are proven and the benefits must be weighed against potential harms in a growing multicancer-detection market.

via The Boston Globe|
#business#cancer#dana-farber