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Egfr T790m

All articles tagged with #egfr t790m

health14 days ago•5 min saved

Rare EGFR Mutation Linked to 62-Fold Lung Cancer Risk in Never-Smokers

A new study in Science identifies a rare inherited EGFR T790M mutation that dramatically increases lung cancer risk, particularly among never-smokers. Researchers found that carriers face 62 times the odds of developing the disease compared to non-carriers who have never smoked, and 25 times the odds overall. The mutation is rare nationwide but significantly more prevalent in Southern Appalachia due to a historical founder effect. While the study does not prove that genetic testing improves outcomes, it suggests future screening could be based on inherited risk rather than just smoking history.

via Fox News|

#23andme #dana-farber #egfr-t790m

health15 days ago•21 min saved

Rare Genetic Mutation Identified as Major Lung Cancer Risk Factor for Non-Smokers

A rare inherited mutation in the EGFR gene, known as T790M, has been identified as a significant risk factor for lung cancer, particularly among non-smokers. A large-scale study involving over 3.3 million individuals found that carriers of this mutation have a 62-fold higher risk of developing lung cancer if they have never smoked, and a 25-fold higher risk overall. The mutation is rare, affecting approximately 1 in 15,850 people, and is most prevalent in populations with Southern Appalachian ancestry. Researchers suggest that genetic testing could lead to earlier screening and detection for at-risk individuals.

via New York Post|

#23andme #dana-farber #egfr-t790m

science22 days ago•14 min saved

Hidden Gene Significantly Elevates Lung-Cancer Risk for Never-Smokers in Appalachia

A rare inherited mutation called EGFR T790M is now linked to a dramatically higher lung-cancer risk, especially among people who never smoked and are from Southern Appalachia (notably Tennessee and Alabama). The gene makes lung cancer roughly 62-fold more likely in never-smokers and about 10-fold more likely in smokers, ranking among the strongest cancer-risk mutations identified. Researchers trace the mutation to ancestors from the British Isles who settled in Appalachia 200–225 years ago, highlighting a regional genetic factor in cancer risk and the potential need for targeted screening.

via The New York Times|

#appalachia #egfr-t790m #genetics