Equilibrium-Driven DNA Computer Achieves Fast, Renewable Computation
A Scaffolded DNA Computer (SDC) computes by steering a programmable DNA energy landscape toward the thermodynamically favored output, removing the need for explicit error-correction and enabling robust, rapid, and renewable molecular computing across at least ten programs (including addition, multiplication, division and parity) with high yields (~95% in typical anneals) and fast sub-minute anneals for small systems; the approach scales to 25 scaffold positions, supports renewals of inputs, and promises energy-efficient DNA data storage and bio-compatible computing applications.
