Tag

Fbxw7

All articles tagged with #fbxw7

Cats and Humans Share Cancer Clues, Shaping New Cross-Species Therapies
science18 days ago

Cats and Humans Share Cancer Clues, Shaping New Cross-Species Therapies

An international study sequenced DNA from 493 feline tumors across 13 cancer types, revealing many shared driver mutations with humans—most notably TP53, with FBXW7 alterations in feline mammary cancers—and identifying UV-signatures in cat skin cancers; the research argues cats are a more relevant cancer model than mice and has released the dataset to researchers to pursue mutation-targeted therapies under the One Health framework, potentially advancing treatments for both cats and people.

Missing Biotin Reveals Cancer Cells' Achilles' Heel
health-and-medicine5 months ago

Missing Biotin Reveals Cancer Cells' Achilles' Heel

Researchers at the University of Lausanne show that cancer cells' ability to bypass glutamine scarcity relies on biotin-activated pyruvate carboxylase; removing biotin disables this bypass, halting growth, and FBXW7 mutations can intensify this vulnerability, suggesting a multi-pathway therapeutic target and explaining why some glutamine-blocking treatments fail.

Biotin-Dependent Route Reveals Cancer’s Hidden Glutamine Bypass
science7 months ago

Biotin-Dependent Route Reveals Cancer’s Hidden Glutamine Bypass

Scientists at the University of Lausanne found that some cancers can keep growing with low glutamine by using a biotin-dependent pathway via pyruvate carboxylase. When the FBXW7 gene is mutated, this bypass is diminished, making cells more glutamine-dependent and explaining resistance to anti-glutamine therapies. The work suggests designing treatments that target multiple metabolic pathways at once.