All articles tagged with #fbxw7
An international study of nearly 500 cat tumors finds shared cancer-causing genes with human cancers, including FBXW7 mutations in feline mammary tumors, suggesting human therapies could be adapted for cats and advancing a One Medicine approach to cancer research.
Researchers at the University of Lausanne show that cancer cells' ability to bypass glutamine scarcity relies on biotin-activated pyruvate carboxylase; removing biotin disables this bypass, halting growth, and FBXW7 mutations can intensify this vulnerability, suggesting a multi-pathway therapeutic target and explaining why some glutamine-blocking treatments fail.
Scientists at the University of Lausanne found that some cancers can keep growing with low glutamine by using a biotin-dependent pathway via pyruvate carboxylase. When the FBXW7 gene is mutated, this bypass is diminished, making cells more glutamine-dependent and explaining resistance to anti-glutamine therapies. The work suggests designing treatments that target multiple metabolic pathways at once.