Two-Step Growth Factor Therapy Sparks Regeneration in Mice
Texas A&M researchers showed that a two-step treatment—first applying FGF2 after wound closure, then BMP2—redirects local fibroblasts to form a blastema-like structure and triggers regrowth of bone, tendons, ligaments, and joints in mice after amputation. The regenerated tissues were not perfectly formed, but the main structures were restored, suggesting latent regenerative capacity in mammals and potential for reducing scarring. Because BMP2 is FDA-approved for some uses and FGF2 is in clinical trials, the approach could move toward clinical testing sooner rather than later.
