Tag

Fibroblasts

All articles tagged with #fibroblasts

science16 days ago•5 min saved

Two-Protein Trick Sparks Partial Toe Regrowth in Mice

Texas A&M researchers coaxed mice toe regrowth by applying two signaling proteins—FGF2 to prime fibroblasts and BMP2 to drive blastema formation—enabling regeneration of bone, tendons, ligaments, and joints across multiple attempts. While imperfect and not yet tested in humans, the work suggests mammals may have latent regenerative potential and could inform future therapies; BMP2 is already used in reconstructive surgery and FGF2 is moving toward clinical use.

via ScienceAlert|

#blastema #bmp2 #fgf2

health22 days ago•8 min saved

Scar-Driven Fibrosis Emerges as Target for Treatment-Resistant Rheumatoid Arthritis

A Nature Immunology study using spatial transcriptomics reveals that persistent scar formation (fibrosis) and disrupted fibroblast–endothelial signaling in RA joints may drive treatment resistance even when inflammation is controlled, pointing to a new fibrosis-focused therapeutic target for patients who don’t respond to standard therapies.

via SciTechDaily|

#fibroblasts #fibrosis #health

health3 months ago•6 min saved

Skin Immune Cells Trigger Hidden Psoriatic Arthritis

Researchers found that immune cells formed in inflamed psoriasis skin can migrate into the bloodstream and travel to joints, where they encounter fibroblasts and ignite inflammation leading to psoriatic arthritis. The study explains why only some psoriasis patients develop arthritis and suggests blood-d detectable migratory cells could serve as an early warning, with future therapies aiming to intercept these cells before joint damage occurs.

via SciTechDaily|

#fibroblasts #health #immune-cells

medicine6 months ago•112 min saved

Fibroblast Niches Drive Crohn’s Fistula Formation

This study uses spatial transcriptomics and single-cell analysis to uncover how specialized fibroblast niches, particularly FAS cells, contribute to the formation, progression, and persistence of Crohn's fistulae, highlighting their roles in tissue remodeling, immune regulation, and epithelial regeneration, with implications for targeted therapies.

via Nature|

#crohns-disease #fibroblasts #fistulae

health2 years ago•3 min saved

"Exploring New Approaches to Erectile Dysfunction Treatment Through Mouse Erection Studies"

A study on mouse erections has revealed the crucial role of fibroblast cells in triggering and maintaining penile erections, shedding light on potential new treatments for erectile dysfunction in humans. The findings suggest that manipulating the Notch signaling pathway in fibroblasts or increasing their absorption of norepinephrine could offer alternative therapeutic approaches. However, rigorous testing is needed to ensure safety and effectiveness in men. This research may provide insights into age-related erectile dysfunction and offer potential alternatives for patients who do not respond to standard drugs like Viagra.

via Livescience.com|

#erectile-dysfunction #fibroblasts #health

health2 years ago•3 min saved

"Reevaluating the Role of Fibroblasts in Penile Erections"

A new study on mice suggests that fibroblasts, connective tissue cells in the penis, play a crucial role in regulating blood flow and mediating erections. The study found that an increased frequency of erections leads to more fibroblasts, while a decreased frequency results in fewer of these cells. The researchers believe that the number of fibroblasts in the penis is affected by the frequency of erections, and older mice had fewer fibroblasts, which was reflected in lower blood flow. The findings may lead to new treatments for erectile dysfunction and suggest that regular erections could be important for maintaining erectile function.

via Medical Xpress|

#erectile-dysfunction #erectile-function #fibroblasts

health2 years ago•57 min saved

Targeting Mid-Old Cells: Unlocking Anti-Aging Interventions for the Elderly

Accumulation of senescent cells in tissues is a major contributor to aging and organ dysfunction. However, a subset of cells in an intermediate stage of cellular senescence, termed "mid-old cells," has been identified. These mid-old cells exhibit distinct gene expression patterns and functional characteristics compared to young and old cells. They are associated with specific inflammation markers and have the capacity to respond to external stimuli. Mid-old cells are found in elderly tissues, particularly in fibroblasts and smooth muscle cells, and contribute to age-related microenvironments. The presence of mid-old cells suggests a potential target for anti-aging interventions in the elderly.

via Nature.com|

#aging #fibroblasts #health

science-and-technology2 years ago•3 min saved

"Revealing the Lizard's Regenerative Power: A Potential Solution for Arthritis"

Researchers from the Keck School of Medicine of USC have identified key cells involved in lizard cartilage regeneration, offering potential insights for treating osteoarthritis. The study uncovers the unique interaction between two cell types, fibroblasts and septoclasts, which enable lizards to regenerate cartilage in their tails. This discovery could pave the way for developing methods to regenerate damaged cartilage in humans, addressing the lack of effective treatments for osteoarthritis.

via SciTechDaily|

#cartilage-regeneration #fibroblasts #lizard-research