Tag

Hla Drb10103

All articles tagged with #hla drb10103

science18 days ago•82 min saved

IL-10 Autoantibodies May Drive Inflammatory Bowel Disease in a Subset of Patients

A 2026 NEJM study analyzing data from more than 4,900 people with inflammatory bowel disease found that about 3.5% carry autoantibodies that block interleukin-10, effectively removing an anti-inflammatory brake and potentially driving disease in this subset; the autoantibibody presence is linked to the HLA-DRB1*01:03 variant, suggesting possibilities for early genetic testing and more targeted, mechanism-based therapies.

via Live Science|

#autoantibodies #hla-drb10103 #inflammatory-bowel-disease

health21 days ago•8 min saved

IL-10 Autoantibodies Reveal a New Subtype of IBD, Pointing to Targeted Therapy

Researchers have identified a subset of inflammatory bowel disease patients whose disease is driven by autoantibodies against interleukin-10, linked to the genetic variant HLA-DRB1*01:03, suggesting a blood test could identify this group and enable personalized therapies that curb inflammation and reduce healthcare costs.

via SciTechDaily|

#autoimmunity #health #hla-drb10103

science23 days ago•5 min saved

Genetic Variant Tied to IBD Drives Disease via IL-10–Neutralizing Antibodies

A UK-Denmark study links the IBD-associated HLA-DRB1*01:03 variant to antibodies that neutralize interleukin-10, removing its anti-inflammatory brake and driving disease in about 3.5% of patients (2.5% Crohn’s, 4.4% ulcerative colitis); the finding, published in The New England Journal of Medicine, points to targeted therapies for this subgroup.

via ScienceAlert|

#autoantibodies #genetics #hla-drb10103