Genetic Variant Tied to IBD Drives Disease via IL-10–Neutralizing Antibodies
TL;DR Summary
A UK-Denmark study links the IBD-associated HLA-DRB1*01:03 variant to antibodies that neutralize interleukin-10, removing its anti-inflammatory brake and driving disease in about 3.5% of patients (2.5% Crohn’s, 4.4% ulcerative colitis); the finding, published in The New England Journal of Medicine, points to targeted therapies for this subgroup.
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- Cell-type-resolved genetic variation shapes inflammatory bowel disease risk Nature
- Genetic marker may flag severe IBD earlier in some patients Medical Xpress
- Scientists Find the Cause of Incurable Bowel Disease Inbox.eu
- Study identifies an important driver of inflammatory bowel disease News-Medical
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