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Inflammatory Bowel Disease

All articles tagged with #inflammatory bowel disease

Creatine May Shield Hippocampal Neurons from Gut Inflammation in Male Rats
health-and-science10 hours ago

Creatine May Shield Hippocampal Neurons from Gut Inflammation in Male Rats

A new study in Brain, Behavior, and Immunity finds that creatine supplementation prevents brain inflammation and neuronal damage in rats with chronic colitis. The protective effects were most pronounced in males, who suffered significant hippocampal cell loss and electrical dysfunction, while females remained largely unaffected at the cellular level. Although creatine is known as a workout supplement, it acts as a cellular energy reserve that may buffer the brain against inflammatory signals from the gut. The findings suggest a potential neuroprotective role for creatine in gut-related brain changes, though the study was conducted in rats and does not confirm efficacy in humans.

via PsyPost|
#creatine#gut-brain-axis#health-and-science
Gut Lining Fragility May Persist in IBD Patients Despite Clinical Remission
health16 hours ago

Gut Lining Fragility May Persist in IBD Patients Despite Clinical Remission

A new study suggests that the cellular vulnerability underlying inflammatory bowel disease (IBD) may persist even when symptoms are controlled. Researchers found that gut lining cells in patients with inactive disease still show abnormal death signals, indicating that clinical remission does not always equate to biological healing. This persistent fragility may explain why the disease frequently flares despite successful treatment.

via ScienceAlert|
#cell-biology#chronic-illness#gut-health
Oxalate Metabolism Defects May Drive Inflammation in IBD Patients
health11 days ago

Oxalate Metabolism Defects May Drive Inflammation in IBD Patients

A new study suggests that a natural compound called oxalate, found in common plant-based foods, may contribute to gut inflammation in people with inflammatory bowel disease (IBD). Researchers found that IBD patients excrete more oxalate than healthy individuals despite similar diets, indicating a defect in how their guts process the compound. This impaired processing appears to trigger immune responses that worsen inflammation, offering a new dietary and therapeutic angle for managing conditions like Crohn's disease and ulcerative colitis.

via ScienceAlert|
#crohns-disease#gut-health#health
Systemic antifungal therapy reshapes the gut microbiome in some IBD patients
health1 month ago

Systemic antifungal therapy reshapes the gut microbiome in some IBD patients

A Nature Medicine study from Weill Cornell compared two weeks of fluconazole (systemic) vs nystatin (mouthwash) in 53 IBD patients with oral thrush. Fluconazole reduced intestinal Candida, remodeled gut fungal and bacterial communities, increased bacterial diversity and butyrate production, and was associated with lower disease activity and slower progression over eight weeks, unlike nystatin. The trial was not randomized or placebo-controlled, so findings are preliminary and justify a larger multicenter trial to confirm efficacy and explore broader patient applicability.

via news.cornell.edu|
#antifungal-therapy#candida-albicans#fluconazole
Fluconazole reshapes the gut microbiome and improves disease activity in IBD
health1 month ago

Fluconazole reshapes the gut microbiome and improves disease activity in IBD

In a prospective study of 53 patients with mild-to-moderate inflammatory bowel disease (UC or Crohn’s), fluconazole reduced gut Candida burden and reshaped the fungal community, triggering cross-kingdom shifts that increased bacterial diversity and boosted butyrate-producer and anti-inflammatory metabolites, correlating with improved disease activity over 8 weeks; oral nystatin did not have these effects, suggesting mycobiome-targeted antifungal therapy may help IBD management.

via Nature|
#antifungal-therapy#candida-albicans#fungal-microbiome
IL-10 Autoantibodies May Drive Inflammatory Bowel Disease in a Subset of Patients
science3 months ago

IL-10 Autoantibodies May Drive Inflammatory Bowel Disease in a Subset of Patients

A 2026 NEJM study analyzing data from more than 4,900 people with inflammatory bowel disease found that about 3.5% carry autoantibodies that block interleukin-10, effectively removing an anti-inflammatory brake and potentially driving disease in this subset; the autoantibibody presence is linked to the HLA-DRB1*01:03 variant, suggesting possibilities for early genetic testing and more targeted, mechanism-based therapies.

via Live Science|
#autoantibodies#hla-drb10103#inflammatory-bowel-disease
science4 months ago

GPR15 directs gut-homing CD8+ regulatory T cells to dampen intestinal inflammation

Researchers identify GPR15 as a marker and homing receptor for a mucosal subset of CD8+ regulatory T cells (CD8+ TIGR) that suppress intestinal inflammation. In humans, GPR15 variants that impair this homing are linked to severe early-onset IBD, and CD8+ TIGR are reduced in sporadic IBD. In mice, GPR15 deficiency hampers colonic homing of these cells, leading to inflammatory macrophage accumulation; CD8+ TIGR can kill activated macrophages via FasL and TWEAK, highlighting a potential new immunotherapeutic avenue for IBD.

via Nature|
#cd8-t-cells#extra-tag#gpr15
Soybean Oil Under Scrutiny: Potential Gut Health Risks in High-Linoleic Diets
science4 months ago

Soybean Oil Under Scrutiny: Potential Gut Health Risks in High-Linoleic Diets

UC Riverside researchers in mice link high soybean oil intake to a disrupted gut microbiome, a leaky intestinal barrier, and greater colitis risk, driven by excess linoleic acid; olive oil may be safer due to lower linoleic acid content, but human implications remain unproven and caution about processed foods is advised.

via SciTechDaily|
#gut-microbiome#inflammatory-bowel-disease#intestinal-barrier
Colon-on-a-chip uncovers stromal drivers, hormonal influences, and cancer risk in IBD
technology4 months ago

Colon-on-a-chip uncovers stromal drivers, hormonal influences, and cancer risk in IBD

A colon-on-a-chip platform using patient-derived epithelium and fibroblasts reproduces healthy and IBD-like tissue, showing IBD fibroblasts drive barrier dysfunction, mucus changes, and inflammation. Peristalsis-like mechanical cues amplify fibrosis and inflammatory signaling in IBD chips, while female hormones exacerbate fibrosis and inflammation specifically in IBD tissues. Tissue-recombinant experiments confirm the stroma as the key driver of barrier breach and cytokine production. When exposed to the carcinogen ENU, IBD chips exhibit greater inflammation, loss of E-cadherin, nuclear β-catenin, and early cancer markers, along with copy-number changes, indicating heightened cancer-initiation risk. The model enables patient-specific studies and tests of stromal-focused therapies and sex-hormone effects on disease progression and cancer risk.

via Nature|
#cancer-progression#fibrosis#inflammatory-bowel-disease
Licorice-Derived Glycyrrhizin Points to New IBD Therapy
science5 months ago

Licorice-Derived Glycyrrhizin Points to New IBD Therapy

Researchers used a lab-grown human intestinal model to screen about 3,500 compounds for treating inflammatory bowel disease (IBD). Glycyrrhizin, a compound from black licorice, emerged as a strong candidate, reducing intestinal cell death and inflammation in the model and showing similar protective effects in mice, indicating potential for clinical development pending further studies.

via SciTechDaily|
#glycyrrhizin#high-throughput-screening#inflammatory-bowel-disease
High-Dose Vitamin D May Help Immune Balance in IBD, Mayo Clinic Study Finds
health5 months ago

High-Dose Vitamin D May Help Immune Balance in IBD, Mayo Clinic Study Finds

A Mayo Clinic-led study in Cell Reports Medicine followed 48 IBD patients with vitamin D deficiency who received weekly high-dose vitamin D (50,000 IU) for 12 weeks. Researchers found vitamin D may rebalance immune responses to gut bacteria, promoting immune tolerance and altering inflammatory signaling, with doses far exceeding typical supplements. While promising for IBD management, researchers caution against self-dosing and note more research is needed.

via Yahoo News Singapore|
#gut-microbiome#health#immune-tolerance
Early Screening Urged for High-Risk Groups Before Age 45
health7 months ago

Early Screening Urged for High-Risk Groups Before Age 45

Colorectal cancer is increasingly affecting adults under 50, prompting doctors to call for earlier screening in high-risk groups even before 45. Official guidance still starts average-risk screening at 45, but those with strong family history, hereditary syndromes (such as Lynch syndrome, FAP, MAP, Peutz–Jeghers, Juvenile Polyposis), or inflammatory bowel disease may need earlier and/or more frequent colonoscopies. Colonoscopy remains the gold standard for detection and prevention by removing precancerous polyps, while stool tests exist as alternatives but are not ideal for high-risk individuals. Red flags like rectal bleeding, persistent changes in bowel habits, abdominal pain, anemia, or unexplained weight loss warrant prompt evaluation regardless of age. Insurance coverage generally aligns with screening guidelines, though diagnostic testing prompted by symptoms can affect costs.

via Fox News|
#colonoscopy#colorectal-cancer#health
Sleep deprivation triggers brain–gut signals that damage gut stem cells
health7 months ago

Sleep deprivation triggers brain–gut signals that damage gut stem cells

New research in Cell Stem Cell shows sleep deprivation in mice activates a brain-to-gut signaling cascade via the vagus nerve, triggering a surge of serotonin in the gut that damages intestinal stem cells and impairs the gut’s regenerative capacity. The study links insomnia to gut dysfunction and suggests acetylcholine from the vagus nerve drives serotonin release, highlighting potential therapeutic targets to protect gut health in sleep-disordered individuals.

via Live Science|
#gut-stem-cells#health#inflammatory-bowel-disease