
Cancer trends explained: more cases, but better outcomes
U.S. cancer incidence has risen from about 400 per 100,000 in 1975 to 456 per 100,000 in 2023, but age-adjusted cancer death rates have fallen since 1999 due to earlier detection and advances in treatment. The rise reflects longer lifespans, broader definitions, and improved screening that uncovers more cases, including slow-growing ones. Cancer starts from DNA errors, caused by random cellular changes, inherited mutations, viruses, or external factors like smoking and UV exposure. In recent decades, targeted therapies and immunotherapies have improved remission and survival, turning many cancers into manageable conditions. Today there are over 18 million US cancer survivors, projected to reach about 26 million by 2040.





