Tag

Intranasal

All articles tagged with #intranasal

science2 days ago•42 min saved

Johns Hopkins Develops Nasal DNA Vaccine to Augment TB Treatment

Johns Hopkins Medicine researchers have created a therapeutic, intranasal DNA vaccine against tuberculosis by fusing RelMtb with Mip3α. When used with standard TB drug therapy, it strengthened lung and systemic immunity, sped bacterial clearance, reduced lung inflammation, and prevented relapse in mice, with durable immune responses observed in nonhuman primates, suggesting a path toward human trials and the potential to shorten TB treatment, including for drug-resistant strains.

via Good News Network|

#dna-vaccine #intranasal #johns-hopkins

health2 years ago•2 min saved

Promising Results for Intranasal COVID Vaccine in Early Trials

Codagenix has announced promising findings for its live-attenuated intranasal COVID vaccine candidate, CoviLiv, which prompted robust humoral and cellular immunity in adults during a phase 1 clinical trial. The vaccine, developed in collaboration with the Serum Institute of India, is currently undergoing a phase 3 efficacy trial as part of the WHO Solidarity vaccine trials. Intranasal vaccines are attractive for their needle-free formulation and potential to stimulate mucosal immunity. Codagenix's vaccine, which is easy to administer and doesn't require refrigeration, may be more appealing for use in low-resource settings. The vaccine mimics natural infection and induces a specific type of local immune response, potentially contributing to hybrid immunity.

via University of Minnesota Twin Cities|

#codagenix #covid-vaccine #health

health3 years ago•2 min saved

Nasal COVID vaccine shows promise.

Clinical trials are underway for an intranasal COVID-19 vaccine that is administered by spraying into the nose, not injecting into the arm. The hope is that a nasal vaccine would be even better at preventing mild illness by inducing immunity in the mucosa of the nasal pharynx, the site of initial viral replication, and may prevent infection and reduce transmission. Nasal vaccines work to immediately strengthen antibodies in the mucus and nose, preventing infection before the virus is able to spread throughout the body. While nasal vaccine doses have already been approved for use in some other parts of the world, they are still in the early stages of human trials in the U.S.

via NewsNation Now|

#clinical-trials #covid-19 #health

health3 years ago•2 min saved

Nasal COVID vaccine shows promise.

Clinical trials are underway for a new type of intranasal COVID-19 vaccine that is administered by spraying into the nose, not injecting into the arm. The hope is that a nasal vaccine would be even better at preventing mild illness by inducing immunity in the mucosa of the nasal pharynx, the site of initial viral replication, and may prevent infection and reduce transmission. While nasal vaccine doses have already been approved for use in some other parts of the world, they are likely still a ways off for the United States.

via PHL17 Philadelphia |

#clinical-trials #covid-19 #health