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Dna Vaccine

All articles tagged with #dna vaccine

biotechnology6 days ago•49 min saved

AI-Designed Universal Vaccine Enters Human Trials with Early Safety Signals

Researchers at the University of Cambridge used AI to identify stable features across the sarbecovirus family and developed a DNA vaccine intended as a broad-spectrum, potentially universal shot. In the first human trial, the vaccine was safe and elicited antibodies recognizing diverse sarbecoviruses, and its needle-free delivery and stability could aid distribution. However, immune responses were modest, and duration of protection, optimal dosing, and real-world efficacy require larger trials; the goal of a universal vaccine remains years away.

via SingularityHub|

#artificial-intelligence #biotechnology #dna-vaccine

science1 month ago•47 min saved

AI-Designed Vaccine Targets Coronavirus Family, Early Trial Shows Promise

Researchers at the University of Cambridge used AI to design a DNA-based vaccine targeting immutable components of the sarbecovirus family (which includes SARS and SARS-CoV-2). In a small first-in-human trial with 39 participants, the AI-designed vaccine activated antibodies and was well tolerated across doses, suggesting potential for a universal coronavirus vaccine, though the durability and magnitude of protection require further study.

via Yahoo|

#ai-designed-vaccine #cambridge #coronaviruses

science1 month ago•5 min saved

AI-Crafted Broad-Spectrum DNA Vaccine Enters First Human Trial

Cambridge researchers used AI to design a DNA vaccine targeting conserved features across the sarbecovirus family (including SARS and related bat viruses) and tested it in humans for the first time. The trial found the vaccine to be safe and capable of inducing antibodies that recognize diverse sarbecoviruses, but the immune response was modest and durability/protection in the real world remain uncertain, necessitating larger trials. If successful, such broad-spectrum, needle-free vaccines could enhance pandemic preparedness and distribution, especially in lower-income regions.

via ScienceAlert|

#ai-design #broad-spectrum #dna-vaccine

technology1 month ago•3 min saved

AI-designed DNA vaccine targets broad coronavirus family in first human trial

Cambridge researchers used AI to design a DNA vaccine that targets conserved features across the sarbecovirus family (including SARS, SARS-CoV-2, and related bat viruses). In the first human trial, the vaccine was safe, delivered without needles, and prompted antibodies recognizing diverse sarbecoviruses, but immune responses were modest and longer trials are needed to assess real-world protection; while a universal, pandemic-proof vaccine is still years away, this marks a meaningful step forward.

via The Conversation|

#ai #broad-spectrum #dna-vaccine

health2 months ago•11 min saved

Tailored DNA Vaccine Extends Survival in Aggressive Glioblastoma

A phase 1 trial of GNOS-PV01, a personalized DNA vaccine for unmethylated MGMT glioblastoma, is safe and elicits broad immune responses by targeting up to 40 patient-specific neoantigens, transforming the tumor microenvironment from cold to hot and reducing the likelihood of tumor escape; results show two-thirds progression-free at six months and two-thirds overall survival at one year, with one patient recurrence-free nearly five years post-diagnosis, supporting larger trials and expansion to all GBM types.

via Neuroscience News|

#dna-vaccine #glioblastoma #health

medical-research2 months ago•15 min saved

Tailored DNA vaccine sparks immune response against glioblastoma in early trial

A phase 1 trial at Siteman Cancer Center shows a personalized neoantigen DNA vaccine (GNOS-PV01) for glioblastoma is safe and elicits robust immune responses; among nine patients, about two-thirds had no progression at six months and two-thirds were alive at one year, including a long-term recurrence-free survivor, indicating potential benefit and the need for larger trials.

via WashU Medicine|

#dna-vaccine #glioblastoma #immunotherapy

science3 months ago•42 min saved

Johns Hopkins Develops Nasal DNA Vaccine to Augment TB Treatment

Johns Hopkins Medicine researchers have created a therapeutic, intranasal DNA vaccine against tuberculosis by fusing RelMtb with Mip3α. When used with standard TB drug therapy, it strengthened lung and systemic immunity, sped bacterial clearance, reduced lung inflammation, and prevented relapse in mice, with durable immune responses observed in nonhuman primates, suggesting a path toward human trials and the potential to shorten TB treatment, including for drug-resistant strains.

via Good News Network|

#dna-vaccine #intranasal #johns-hopkins