Tag

Lean Body Mass

All articles tagged with #lean body mass

health1 month ago•8 min saved

GLP-1 Weight Loss: Muscle Loss Not a Unique Risk, Experts Say

At ADA 2026, experts debated GLP-1–driven weight loss and muscle loss. The consensus is that most weight loss with GLP-1s is fat rather than lean mass, with no solid evidence that GLP-1 therapies cause frailty or sarcopenia overall. Concern is greatest for high‑risk groups (older adults, menopausal women, sarcopenic obesity), where large lean-mass losses could be problematic. Measurement issues matter: DEXA often misrepresents skeletal muscle; D3-creatine dilution provides a more direct assessment and links low muscle mass to worse outcomes. Exercise and adequate protein remain essential to preserve muscle, and some patients may improve function despite lean-mass loss. Weight regain can negate benefits, underscoring the need for monitoring and resistance training in older patients; pharmacologic approaches to protect lean mass are in development.

via Medscape|

#aging #glp-1 #health

science2 months ago•42 min saved

Muscle-Sparing drug combo shows promise during weight loss

A Nature study (EMBRAZE) found that adding apitegromab, an anti-myostatin monoclonal antibody, to tirzepatide helps preserve lean mass while supporting fat loss in adults with overweight or obesity. Over 24 weeks and 102 participants, those on the combo lost less lean mass and about 85% of total weight loss came from fat; adverse events were higher with the combination (76% vs 71%). The trial excluded individuals with diabetes, heart disease, stroke, vascular disorders or active cancer, and the results provide clinical proof of concept for muscle-sparing approaches to GLP-1–based weight loss therapy.

via Yahoo|

#lean-body-mass #myostatin #obesity

health4 months ago•0 min saved

Tirzepatide may deliver bigger weight loss but greater lean-mass loss vs semaglutide, study suggests

A new study suggests Lilly’s tirzepatide yields more weight loss than Novo Nordisk’s semaglutide, but may also cause greater loss of lean body mass, indicating a potential trade-off in body composition.

via Endpoints News|

#glp-1 #health #lean-body-mass

health3 years ago•4 min saved

"Non-Fat Tissue Mass Linked to Lower Alzheimer's Risk and Improved Cognitive Performance"

Individuals with higher genetically estimated lean body mass have a lower risk of developing Alzheimer's disease, according to a study using genetic data from the UK Biobank. The study also found that those with higher lean mass in their arms and legs tend to have better cognitive performance. The research suggests that lean mass may be a potential modifiable protective factor for Alzheimer's disease, although further investigation is needed to understand the underlying mechanisms and implications.

via PsyPost|

#alzheimers-disease #cognitive-performance #genetic-data

health3 years ago•3 min saved

Obesity Speeds Up Alcohol Metabolism in Women

Women with obesity and older women clear alcohol from their systems 52% faster than women of healthy weights and younger women, according to a new study. The rate at which alcohol is eliminated from the bloodstream is largely predicted by lean body mass, with lean liver tissue playing a role in metabolizing alcohol. The study analyzed data from 143 women and found that higher fat-free body mass was associated with a faster alcohol elimination rate. The findings also shed light on alcohol metabolism in women who have undergone weight loss surgery, indicating that surgery-induced reductions in lean body mass can affect alcohol elimination rates.

via Technology Networks|

#alcohol-metabolism #bariatric-surgery #health