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Long Term Potentiation

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Reviving Frozen Brain Slices Signals a Leap Toward Cryopreserved Organs
science20 days ago

Reviving Frozen Brain Slices Signals a Leap Toward Cryopreserved Organs

German researchers vitrified 350-micron mouse brain slices, cooled them to -320°F, and after thawing found intact neuronal membranes and preserved hippocampal long-term potentiation, with neurons still responsive to stimulation, suggesting brain function can resume after complete molecular shutdown and opening a path to organ preservation and potential cryopreservation of whole mammals, though translating this to humans and larger organs will require improved vitrification, cooling, and rewarming techniques.