Tag

Lung

All articles tagged with #lung

science1 month ago•106 min saved

Lung-resident immune cells reveal hidden genetic drivers of autoimmune and lung diseases

A large single-cell eQTL study across 29 lung immune cell subsets from 120 individuals links disease-risk variants to gene expression in tissue-resident immune cells, revealing cell-type–specific regulatory mechanisms for autoimmune diseases and COPD. The researchers identify thousands of eGenes, with hundreds showing colocalization to GWAS signals; COPD heritability is estimated at 15–20% mediated by lung-immune-cell expression, and genes like IRF5, IFITM3, and ZNF683 illustrate how regulatory variants shape immune responses in the lung. Many signals are not detected in blood-based eQTL datasets, highlighting the value of studying tissue-resident cells.

via nature.com|

#copd #eqtl #lung

health4 months ago•16 min saved

Forest Fire Smoke Can Form Dark Lung Casts, Case Reveals

A Chinese man exposed to thick forest-fire smoke developed rubbery, soot-colored bronchial casts that blocked his airways. Clinicians removed the casts with a cryoprobe after intubation, and the patient recovered with a week of hospital care for pneumonia, breathing normally at follow-up. Published in the NEJM, the case highlights hidden health risks from climate-change–driven wildfires that may become more common.

via Gizmodo|

#climate-change #health #lung

science6 months ago•7 min saved

Molecular Switch Could Unlock Lungs' Self-Healing, Mayo Study Finds

Mayo Clinic researchers uncovered a molecular circuit that decides whether alveolar type 2 (AT2) lung cells repair tissue or defend against infection; a clamp-like regulator, C/EBPα, must be released after injury, with PRC2 and DLK1 timing the switch. The finding explains why infections slow lung healing and suggests regenerative therapies that modulate C/EBPα or reprogram AT2 cells, potentially enabling cell replacement. Published in Nature Communications (2025), the work also points to early-detection biomarkers and ties to Mayo's Precure and Genesis initiatives.

via SciTechDaily|

#at2-cells #cebpa #lung

health3 years ago•2 min saved

Dolph Lundgren's Cancer Battle During 'Aquaman 2' Filming.

Actor Dolph Lundgren revealed that he has been privately battling cancer on and off for the last eight years. Doctors first discovered and removed a cancerous tumor on the actor’s kidney in 2015. Lundgren said six more tumors were discovered in 2020, and more tumors were discovered in the fall of 2021. Lundgren eventually got a second opinion from a doctor in London who discovered that his kidney cancer was mutating more like lung cancer. The new treatment started shrinking his tumors by around 20% and 30% within a three-month period. Lundgren is reprising his roles in "Aquaman and the Lost Kingdom" and "The Expendables 4."

via Variety|

#cancer #dolph-lundgren #health