Tag

Copd

All articles tagged with #copd

science22 days ago•106 min saved

Lung-resident immune cells reveal hidden genetic drivers of autoimmune and lung diseases

A large single-cell eQTL study across 29 lung immune cell subsets from 120 individuals links disease-risk variants to gene expression in tissue-resident immune cells, revealing cell-type–specific regulatory mechanisms for autoimmune diseases and COPD. The researchers identify thousands of eGenes, with hundreds showing colocalization to GWAS signals; COPD heritability is estimated at 15–20% mediated by lung-immune-cell expression, and genes like IRF5, IFITM3, and ZNF683 illustrate how regulatory variants shape immune responses in the lung. Many signals are not detected in blood-based eQTL datasets, highlighting the value of studying tissue-resident cells.

via nature.com|

#copd #eqtl #lung

technology25 days ago•11 min saved

AI-powered remote care slashes COPD and asthma hospitalizations

Intermountain Health and CareCentra’s iCARE program monitored about 1,200 COPD and adult asthma patients across five Utah hospitals over two years using an AI-enabled platform fed by spirometers, pulse oximeters, connected inhaler devices, and wearables. The system detects early deterioration, nudges patients, and escalates to pulmonary navigators, cutting hospitalizations by 50%, emergency visits by 20%, and total care costs by 57% while increasing navigator capacity from roughly 30 to about 220 patients. Results were shared at the ATS 2026 conference, with plans to scale the technology across 34 hospitals.

via KSL.com|

#ai #asthma #copd

health1 month ago•37 min saved

Leafy Greens Linked to Lower COPD Risk via Vitamin K1

A large Australian study from Edith Cowan University, published in The American Journal of Clinical Nutrition, found that higher dietary vitamin K1 from leafy greens (e.g., spinach and kale) is linked to a lower risk of chronic obstructive pulmonary disease (COPD). Over 179,000 adults were followed for a decade, and those with the highest K1 intake were about 16% less likely to develop COPD and showed stronger lung function. The researchers suggest vitamin K1 helps protect lung elastic fibers, while vitamin K2 did not reduce COPD risk. Smoking remains the major COPD risk factor, with diet possibly counteracting some damage but not replacing quitting and pollution reduction.

via CTV News|

#copd #health #leafy-greens

health1 month ago•5 min saved

Leafy greens linked to lower COPD risk, new study suggests

In a large observational study of 179,062 people over about 10.5 years, higher vitamin K1 intake—mainly from leafy greens like spinach and kale—was associated with better lung function and a 16% lower COPD risk, with stronger effects among smokers and those in high-risk occupations; vitamin K2 showed no link. While not proving causation, researchers say increasing leafy greens could be a practical way to boost lung health by raising vitamin K1 intake.

via Fox News|

#copd #diet-and-nutrition #health

healthcare5 months ago•2 min saved

AZ's tozorakimab delivers COPD benefit across populations in Phase 3

AstraZeneca's anti-IL-33 antibody tozorakimab posted positive Phase 3 results in COPD (Oberon and Titania), reducing the annualized rate of moderate-to-severe exacerbations versus placebo in former smokers and showing benefit across the overall population, with a favorable safety profile. The drug’s supposed differentiation comes from complete inhibition of ST2 and RAGE/EGFR signaling, unlike rivals Roche and Sanofi/Regeneron’s IL-33 blockers that produced mixed results. AZ plans to present full data at an upcoming meeting and is pursuing two additional Phase 3 trials (Prospero, Miranda), while maintaining a target of potentially $3–5 billion in peak sales if approved.

via Fierce Biotech|

#astrazeneca #copd #healthcare

health5 months ago•55 min saved

COPD relief hinges on one step: quitting smoking, says GP

GP Dr Philippa Kaye explains COPD is a chronic, incurable lung condition often linked to smoking; while not curable, symptoms can be markedly improved by quitting smoking (the single most important step), engaging in supervised exercise via a pulmonary rehabilitation program, using inhalers correctly, maintaining a healthy weight, and staying up to date with vaccines (flu, pneumococcal, RSV). Seek GP help if breathlessness or coughing worsens.

via Daily Mail|

#copd #health #inhalers

entertainment6 months ago•5 min saved

Chuck Negron, Frontman Behind Three Dog Night's Classic Hits, Dies at 83

Chuck Negron, founding lead singer of Three Dog Night behind hits like 'Joy to the World' and 'One,' died at 83 in Studio City from complications of heart failure and COPD; once plagued by drug issues, he sobered in 1991 and later reconciled with bandmates. He is survived by his wife Ami Albea Negron and five children, including Berry Oakley Jr.

via Fox News|

#chuck-negron #copd #entertainment

obituaries6 months ago•17 min saved

Chuck Negron, Frontman of Three Dog Night, Dies at 83

Chuck Negron, founding member and lead vocalist of the LA rock band Three Dog Night, died at 83 in Studio City after battling COPD and heart failure. Born Charles Negron II in 1942 in the Bronx, he helped form Three Dog Night in 1967 with Danny Hutton and Cory Wells, delivering hits like Joy To The World and One. The group underwent lineup changes amid internal tensions and Negron’s struggles with addiction, though he later pursued a solo career and wrote an autobiography; he and Hutton reportedly reconciled last year. He is survived by his wife Ami Albea Negron and several children and relatives.

via Deadline|

#chuck-negron #copd #obituaries

entertainment6 months ago•3 min saved

Chuck Negron, Frontman Behind Three Dog Night’s Classic Hits, Dies at 83

Chuck Negron, a founding member and lead vocalist of Three Dog Night, died at 83 in Los Angeles from complications of heart failure and COPD. He powered a string of late-1960s/early-70s hits including Joy to the World, One and An Old Fashioned Love Song, and also sang Easy To Be Hard and The Show Must Go On. Negron battled drug issues during the band’s rise, spent time in rehab, and found sobriety in 1991, later pursuing a solo career and writing Three Dog Nightmare. After years of estrangement, he reconciled with fellow member Danny Hutton last year. He is survived by wife Ami Albea Negron and five children, including Berry Oakley Jr.,

via CBS News|

#chuck-negron #copd #entertainment

music6 months ago•15 min saved

Chuck Negron, the Voice Behind Three Dog Night, Dies at 83

Chuck Negron, co-founder and lead singer of Three Dog Night, died at 83 at his Studio City home after decades-long COPD; he helped the band reach peak fame with hits like One and Joy to the World but battled heroin addiction that led to years on Skid Row and multiple rehab stints as the group split in 1976, reformed in 1982, and finally broke up again in 1985; Negron later pursued a solo career and published a memoir, Cory Wells died in 2015, and Danny Hutton still tours with Three Dog Night, with Negron and Hutton reportedly burying the hatchet last year.

via Rolling Stone|

#chuck-negron #copd #joy-to-the-world

obituaries6 months ago•18 min saved

Chuck Negron, Three Dog Night’s Golden‑voiced Frontman, Dies at 83

Chuck Negron, co‑founder and lead singer of Three Dog Night and the voice behind hits like Joy to the World and One, died at 83 at his Studio City home. The band chalked up 21 Top 40 hits and gold albums, but Negron battled heroin addiction and COPD for decades, pursued rehab in 1991, and ultimately reconciled with former bandmates. His legacy endures in the trio’s classic catalog and his later solo work.

via Variety|

#chuck-negron #copd #joy-to-the-world

health7 months ago•5 min saved

Winded by Stairs? How to Tell Normal Breathlessness From a Health Red Flag

Feeling winded after climbing stairs can be a normal physiological response because stairs demand more oxygen and energy, but new or prolonged breathlessness warrants medical evaluation to rule out underlying conditions such as heart failure, obesity, COPD, or anemia. If recovery is quick, it’s usually not concerning; if breathing stays elevated for more than about three minutes or is accompanied by chest pain, headaches, or vision changes, consult a doctor. To improve stair endurance, gradually train and strengthen the muscles involved while addressing any medical issues first.

via HuffPost|

#breathlessness #copd #endurance-training

health1 year ago•5 min saved

Younger People at Risk of Dangerous COPD

A new study highlights that COPD can affect people under 50, with 4.5% of adults in this age group diagnosed, and that early onset COPD is linked to higher risks of hospitalization and death. Smoking remains the primary risk factor, but non-smokers can also develop COPD. Early diagnosis and lifestyle changes, including quitting smoking and vaccination, are crucial for managing the disease and improving outcomes.

via CNN|

#copd #health #lung-disease

business1 year ago•4 min saved

GSK and Hengrui Pharma Announce $12.5 Billion Multi-Asset Collaboration

GSK and Hengrui Pharma have entered into agreements to develop up to 12 innovative medicines, including a potential best-in-class PDE3/4 inhibitor for COPD, with GSK paying $500 million upfront and the potential for up to $12 billion in milestone payments, aiming to expand their pipelines in respiratory, immunology, inflammation, and oncology.

via GSK|

#business #copd #gsk

business1 year ago•15 min saved

Merck to Acquire Verona Pharma, Launching First-In-Class COPD Treatment Ohtuvayre®

Merck is acquiring Verona Pharma for approximately $10 billion to expand its portfolio with Ohtuvayre, a first-in-class COPD treatment approved by the FDA, aiming to enhance growth and innovation in respiratory therapies.

via Merck.com|

#acquisition #business #copd