All articles tagged with #nephrology
CSL has agreed to pay $355 million upfront and up to $1.2 billion in milestones to co-develop and co-commercialize Alentis Therapeutics' phase 2 fibrosis drug, lixudebart. The deal grants CSL 55% of profits and funding for trials in kidney and liver diseases, including a phase 3 study for antineutrophil cytoplasmic antibodies-associated vasculitis.
Biogen will acquire Apellis for $41 per share in cash (about $5.6 billion) plus a contingent value right tied to SYFOVRE’s sales, adding two approved medicines—EMPAVELI and SYFOVRE—to Biogen’s growth portfolio and accelerating Biogen’s nephrology plans with Apellis’ team; 2025 combined net product revenue for EMPAVELI and SYFOVRE was $689 million and is expected to grow mid-to-high teens through 2028. Closing is anticipated in Q2 2026, financed by cash and borrowings with plans to de-leverage by 2027. Apellis’ US sales capabilities and nephrology expertise will bolster Biogen’s readiness for felzartamab in Phase 3, while Sobi retains EMPAVELI rights outside the U.S.; the CVR pays up to two $2-per-share amounts based on SYFOVRE sales thresholds and a possible $4-per-share payment in 2031 if higher sales are reached.
Dr. Nishchay emphasizes the importance of awareness and early detection of kidney disease, which often shows no early symptoms. Key signs include fatigue, poor appetite, swelling, and changes in urination. Since early symptoms are vague, routine tests are crucial for diagnosis and prevention of progression, highlighting the vital role of kidneys in overall health.
Dr. Sai Nayar, a nephrologist with CoxHealth, emphasizes the importance of understanding kidney function and maintaining kidney health during National Kidney Month. Chronic kidney disease, often linked to diabetes and high blood pressure, can lead to serious health issues. Early detection and proactive measures such as monitoring blood pressure, managing diabetes, and staying hydrated can help mitigate the risk of chronic kidney disease. Education and proactive communication with healthcare providers are crucial in preventing and understanding kidney issues.