Tag

Neuropathology

All articles tagged with #neuropathology

science11 hours ago•88 min saved

Consensus GWAS uncovers 91 ADRD risk loci and ties polygenic risk to Alzheimer’s pathology

A European-ancestry meta-analysis of ADRD GWAS (128,681 cases/proxy; 849,833 controls) identified 91 genome-wide loci, including 16 new ones, with 56 loci influencing clinically diagnosed Alzheimer’s disease (18 tier-2 loci needing external validation). Excluding APOE, polygenic scores were linked to AD pathology: in top-decile individuals, Braak stage >4 and moderate/severe neuritic plaques at death were about 2× more likely, though overall predictive power is modest (roughly 4% of variance explained; small AUC gains). Results held across main, no-proxy, and no-biobank analyses and showed microglia enrichment and pathways tied to tau, amyloid, lipids, and immunity; genetic correlations connected ADRD with Lewy body dementia, ALS, PD and educational attainment. The authors call for larger well-characterized neuropathology datasets to clarify locus effects on AD pathology versus other dementias and provide further external validation for certain loci and no-proxy/no-biobank statistics for broader use.

via Nature|

#alzheimers-disease #genomics #gwas

health8 months ago•3 min saved

Research Uncovers Hidden Brain Damage and Vascular Causes of Dementia

Scientists at the University of New Mexico have identified hidden brain damage linked to vascular dementia, including the presence of nano- and microplastics, which may also contribute to Alzheimer's disease, highlighting the need for new classification and treatment approaches.

via ScienceDaily|

#alzheimers-disease #brain-damage #health

health8 months ago•3 min saved

Nanoplastics Linked to Increased Risk of Alzheimer’s and Brain Cell Disruption

A new study highlights the complex role of small blood vessel damage and the presence of microplastics in the brain as contributors to dementia, suggesting the need for revised diagnostic methods and further research into environmental factors affecting brain health.

via SciTechDaily|

#alzheimers #brain-health #health

health2 years ago•14 min saved

"Tragic Case Study: Woman's Brain Reveals Worst-Case Scenario for Alzheimer's"

Researchers have published postmortem data from a woman who died after receiving three doses of the anti-amyloid antibody lecanemab, showing extensive vascular inflammation and numerous ruptured blood vessels throughout her brain. The autopsy revealed that she likely died of complications from lecanemab treatment due to her previously unrecognized risk factors, including being an APOE4 homozygote with severe cerebral amyloid angiopathy. The findings suggest that careful screening for signs of cerebral amyloid angiopathy is crucial for potential immunotherapy patients to avoid similar outcomes. The study also highlights the need for more rigorous baseline evaluation and close monitoring during treatment to prevent severe amyloid-related imaging abnormalities (ARIA).

via Alzforum|

#alzheimers-disease #aria #health